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dc.contributor.authorStafford, K.A.
dc.contributor.authorNganga, L.W.
dc.contributor.authorTulli, T.
dc.date.accessioned2019-04-29T19:01:01Z
dc.date.available2019-04-29T19:01:01Z
dc.date.issued2018
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85059188340&doi=10.1177%2f2325958218759602&partnerID=40&md5=dad1768ef97d5956c44cdf6cceb21c1a
dc.identifier.urihttp://hdl.handle.net/10713/8953
dc.description.abstractThe World Health Organization recommended removing all CD4 requirements for initiation of antiretroviral therapy (ART) in resource-limited settings. We examined the pre-ART period to identify and assess factors associated with outcomes of pre-ART care. Four modes of transition out of pre-ART care were considered. Beta estimates from the competing risks Cox models were used to investigate whether the effects of covariates differed by mode of transition. Median CD4 counts at entry showed no meaningful change over time. Advanced disease progression and presence of opportunistic infections were significant predictors of pre-ART mortality. Men were more likely to die before initiating ART, transfer to another facility, or be lost to follow-up than were women. Removing CD4 thresholds is not likely to substantially reduce program mortality prior to ART initiation unless and until patients enroll earlier in disease progression. Care programs should focus on diagnosis and treatment of opportunistic infections to reduce pre-ART mortality. Copyright The Author(s) 2018.en_US
dc.description.urihttps://dx.doi.org/10.1177/2325958218759602en_US
dc.language.isoen_USen_US
dc.publisherSAGE Publications Inc.en_US
dc.relation.ispartofJournal of the International Association of Providers of AIDS Care
dc.subjectcompeting risks analysisen_US
dc.subjectHIVen_US
dc.subjectopportunistic infectionsen_US
dc.subjectpre-ART perioden_US
dc.subjecttreatment guidelinesen_US
dc.titleFactors Associated with Outcomes of Pre-ART HIV Careen_US
dc.typeArticleen_US
dc.identifier.doi10.1177/2325958218759602


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