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    An integromic signature for lung cancer early detection

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    Author
    Leng, Q.
    Lin, Y.
    Zhan, M.
    Date
    2018
    Journal
    Oncotarget
    Publisher
    Impact Journals LLC
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://dx.doi.org/10.18632/oncotarget.25227
    Abstract
    We previously developed three microRNAs (miRs-21, 210, and 486-5p), two long noncoding RNAs (lncRNAs) (SNHG1 and RMRP), and two fucosyltransferase (FUT) genes (FUT8 and POFUT1) as potential plasma biomarkers for lung cancer. However, the diagnostic performance of the individual panels is not sufficient to be used in the clinics. Given the heterogeneity of lung tumors developed from multifactorial molecular aberrations, we determine whether integrating the different classes of molecular biomarkers can improve diagnosis of lung cancer. By using droplet digital PCR, we analyze expression of the seven genes in plasma of a development cohort of 64 lung cancer patients and 33 cancer-free individuals. The panels of three miRNAs (miRs-21, 210, and 486-5p), two lncRNAs (SNHG1 and RMRP), and two FUTs (FUT8 and POFUT1) have a sensitivity of 81-86% and a specificity of 84-87% for diagnosis of lung cancer. From the seven genes, an integromic plasma signature comprising miR-210, SNHG1, and FUT8 is developed that produces higher sensitivity (95.45%) and specificity (96.97%) compared with the individual biomarker panels (all p < 0.05). The diagnostic value of the signature was confirmed in a validation cohort of 40 lung cancer patients and 29 controls, independent of stage and histological type of lung tumor, and patients' age, sex, and smoking status (all p > 0.05). The integration of the different categories of biomarkers might improve diagnosis of lung cancer. Copyright Leng et al.
    Sponsors
    This work was supported in part by NCI R21CA205746, VA Merit Award I01 CX000512, Award from the Geaton and JoAnn DeCesaris Family Foundation, UMD-UMB Research and Innovation Seed Grant, DoD-Idea Development Award, and Maryland Innovation Initiative (MII) Commercialization Program-Phase 1/2 Grant (F.J.).
    Keyword
    Biomarkers
    Diagnosis
    Early stage
    Lung cancer
    Plasma
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85046953920&doi=10.18632%2foncotarget.25227&partnerID=40&md5=5dc171b10aa4d551f0b83bdc27c04f69; http://hdl.handle.net/10713/8944
    ae974a485f413a2113503eed53cd6c53
    10.18632/oncotarget.25227
    Scopus Count
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