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dc.contributor.authorKaze, A.D.
dc.contributor.authorIlori, T.
dc.contributor.authorJaar, B.G.
dc.date.accessioned2019-04-29T19:01:00Z
dc.date.available2019-04-29T19:01:00Z
dc.date.issued2018
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85047953428&doi=10.1186%2fs12882-018-0930-5&partnerID=40&md5=82303a9e45215504a271e46e0a49b468
dc.identifier.urihttp://hdl.handle.net/10713/8942
dc.description.abstractBackground: Accurate contemporary data on the burden of Chronic Kidney Disease (CKD) on the African continent are lacking. We determined the prevalence of CKD in adult populations living in Africa, and variations by stage, gender, estimated Glomerular Filtration Rate (eGFR) equation, and residence. Methods: For this systematic review, we searched multiple electronic databases for original studies on CKD prevalence reported from January 1, 2000 to December 31, 2016. Two reviewers independently undertook quality assessment and data extraction. We stabilized the variance of study-specific estimates with the Freeman-Turkey single arcsine transformation and pooled the data using a random effects meta-analysis models. Results: A total of 98 studies involving 98,432 individuals were included in the final meta-analysis. The overall prevalence was 15.8% (95% CI 12.1-19.9) for CKD stages 1-5 and 4.6% (3.3-6.1) for CKD stages 3-5 in the general population. Equivalent figures were greater at 32.3% (23.4-41.8) and 13.3% (10.7-16.0) in high-risk populations (people with hypertension, diabetes, HIV). CKD prevalence was higher in studies based on the Cockcroft-Gault formula than MDRD or CKD-EPI equations; and in studies from sub-Saharan Africa compared with those from North Africa (17.7, 95% CI 13.7-22.1 vs 6.1, 95% CI 3.6-9.3, p < 0.001). There was substantial heterogeneity across studies (all I2 > 90%) and no evidence of publication bias in main analyses. Conclusion: CKD is highly prevalent across Africa, inviting efforts into prevention, early detection and control of CKD in adults living on the African continent which is particularly important in a resource limited environment. Trial Registration: Prospero Registration ID: CRD42017054445. Copyright 2018 The Author(s).en_US
dc.description.urihttps://dx.doi.org/10.1186/s12882-018-0930-5en_US
dc.language.isoen_USen_US
dc.publisherBioMed Central Ltd.en_US
dc.relation.ispartofBMC Nephrology
dc.subjectAfricaen_US
dc.subjectChronic kidney diseaseen_US
dc.subjectMeta-analysisen_US
dc.subjectPrevalenceen_US
dc.subjectSystematic reviewen_US
dc.titleBurden of chronic kidney disease on the African continent: A systematic review and meta-analysisen_US
dc.typeReviewen_US
dc.identifier.doi10.1186/s12882-018-0930-5
dc.identifier.pmid29859046


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