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    Burden of chronic kidney disease on the African continent: A systematic review and meta-analysis

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    Author
    Kaze, A.D.
    Ilori, T.
    Jaar, B.G.
    Date
    2018
    Journal
    BMC Nephrology
    Publisher
    BioMed Central Ltd.
    Type
    Review
    
    Metadata
    Show full item record
    See at
    https://dx.doi.org/10.1186/s12882-018-0930-5
    Abstract
    Background: Accurate contemporary data on the burden of Chronic Kidney Disease (CKD) on the African continent are lacking. We determined the prevalence of CKD in adult populations living in Africa, and variations by stage, gender, estimated Glomerular Filtration Rate (eGFR) equation, and residence. Methods: For this systematic review, we searched multiple electronic databases for original studies on CKD prevalence reported from January 1, 2000 to December 31, 2016. Two reviewers independently undertook quality assessment and data extraction. We stabilized the variance of study-specific estimates with the Freeman-Turkey single arcsine transformation and pooled the data using a random effects meta-analysis models. Results: A total of 98 studies involving 98,432 individuals were included in the final meta-analysis. The overall prevalence was 15.8% (95% CI 12.1-19.9) for CKD stages 1-5 and 4.6% (3.3-6.1) for CKD stages 3-5 in the general population. Equivalent figures were greater at 32.3% (23.4-41.8) and 13.3% (10.7-16.0) in high-risk populations (people with hypertension, diabetes, HIV). CKD prevalence was higher in studies based on the Cockcroft-Gault formula than MDRD or CKD-EPI equations; and in studies from sub-Saharan Africa compared with those from North Africa (17.7, 95% CI 13.7-22.1 vs 6.1, 95% CI 3.6-9.3, p < 0.001). There was substantial heterogeneity across studies (all I2 > 90%) and no evidence of publication bias in main analyses. Conclusion: CKD is highly prevalent across Africa, inviting efforts into prevention, early detection and control of CKD in adults living on the African continent which is particularly important in a resource limited environment. Trial Registration: Prospero Registration ID: CRD42017054445. Copyright 2018 The Author(s).
    Keyword
    Africa
    Chronic kidney disease
    Meta-analysis
    Prevalence
    Systematic review
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85047953428&doi=10.1186%2fs12882-018-0930-5&partnerID=40&md5=82303a9e45215504a271e46e0a49b468; http://hdl.handle.net/10713/8942
    ae974a485f413a2113503eed53cd6c53
    10.1186/s12882-018-0930-5
    Scopus Count
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    UMB Open Access Articles 2018

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