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    Orbitofrontal neurons signal reward predictions, not reward prediction errors

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    Author
    Stalnaker, T.A.
    Liu, T.-L.
    Takahashi, Y.K.
    Date
    2018
    Journal
    Neurobiology of Learning and Memory
    Publisher
    Academic Press Inc.
    Type
    Article
    
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    See at
    https://dx.doi.org/10.1016/j.nlm.2018.01.013
    Abstract
    Neurons in the orbitofrontal cortex (OFC) fire in anticipation of and during rewards. Such firing has been suggested to encode reward predictions and to account in some way for the role of this area in adaptive behavior and learning. However, it has also been reported that neural activity in OFC reflects reward prediction errors, which might drive learning directly. Here we tested this question by analyzing the firing of OFC neurons recorded in an odor discrimination task in which rats were trained to sample odor cues and respond left or right on each trial for reward. Neurons were recorded across blocks of trials in which we switched either the number or the flavor of the reward delivered in each well. Previously we have described how neurons in this dataset fired to the predictive cues (Stalnaker et al., 2014); here we focused on the firing in anticipation of and just after delivery of each drop of reward, looking specifically for differences in firing based on whether the reward number or flavor was unexpected or expected. Unlike dopamine neurons recorded in this setting, which exhibited phasic error-like responses after surprising changes in either reward number or reward flavor (Takahashi et al., 2017), OFC neurons showed no such error correlates and instead fired in a way that reflected reward predictions. Copyright 2018
    Sponsors
    This work was supported by funding from NIDA . The opinions expressed in this article are the authors' own and do not reflect the view of the National Institutes of Health, the Department of Health and Human Services, or the United States government.
    Keyword
    Learning
    Orbitofrontal
    Rat
    Reward prediction error
    Single unit
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041581235&doi=10.1016%2fj.nlm.2018.01.013&partnerID=40&md5=9b0d4019b18b768a3e4366736bfcebcd; http://hdl.handle.net/10713/8924
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.nlm.2018.01.013
    Scopus Count
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    UMB Open Access Articles 2018

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