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    Dosimetric characterization of an intensity-modulated X-ray brachytherapy system

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    Author
    Lee, S.-W.
    Sozontov, E.
    Strumban, E.
    Date
    2018
    Journal
    Journal of Medical Physics
    Publisher
    Wolters Kluwer Medknow Publications
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://dx.doi.org/10.4103/jmp.JMP_52_18
    Abstract
    Purpose: An intensity-modulated X-ray brachytherapy system is being developed for various clinical applications. This new system makes it possible for clinical staff to control energy as well as dose rate for different tumor sites according to their sizes and radiobiological characteristics. Materials and Methods: This system is mainly composed of an X-ray tube, guide tube collimation, and secondary (pseudo) target. Due to its configuration, convenient modulations of fluorescent X-ray energy and intensity are possible. To observe applicability of this novel system for various primary and secondary target combinations, Monte Carlo simulation using MCNP5 was performed, and air measurements were done. As a primary and pseudo-target combination, silver-molybdenum (Ag-Mo), tungsten-neodymium (W-Nd), and tungsten-erbium (W-Er) were used for the calculation for dose profile. Specifically, a dose distribution was calculated around each of these target combinations. Dose distributions as a function of target angles were also calculated. The Ag-Mo combination was analyzed for Cartesian coordinates of xy, xz, and yz planes of the pseudo-target to observe dose distribution as a function of the angle of secondary target. Results: The results showed that radial dose fall-off of Ag-Mo was greater than commercially available brachytherapy sources ( 103 Pd and 125 I) due to its low characteristic X-ray energy. Conclusions: Dose distribution variance should be considered in beam modulation for clinical application. Dynamic movement of the pseudo-target is feasible and remains as a subject for future research. Copyright 2018 Journal of Medical Physics.
    Keyword
    Brachytherapy
    dosimetry
    intensity modulated
    X-ray
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85058777968&doi=10.4103%2fjmp.JMP_52_18&partnerID=40&md5=f35f6a62665f5850c9e709a0d0446a55; http://hdl.handle.net/10713/8920
    ae974a485f413a2113503eed53cd6c53
    10.4103/jmp.JMP_52_18
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