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dc.contributor.authorJonas, S.N.
dc.contributor.authorIzbudak, I.
dc.contributor.authorFrazier, A.A.
dc.date.accessioned2019-04-29T19:00:58Z
dc.date.available2019-04-29T19:00:58Z
dc.date.issued2018
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85054595829&doi=10.3174%2fajnr.A5796&partnerID=40&md5=4d60831b0686f564c7c2ba3155a02954
dc.identifier.urihttp://hdl.handle.net/10713/8918
dc.description.abstractBACKGROUND AND PURPOSE: Preliminary research has demonstrated that postgadolinium 3D-FLAIR MR imaging at 7T may be a valuable tool for detecting abnormal meningeal enhancement and inflammation in MS; however, researchers have not systematically investigated its longitudinal persistence.Wehypothesized that persistence of meningeal enhancement in MS varies on the basis of pattern of enhancement as well as demographic and clinical factors such as treatment status, disease phenotype, and disability score. MATERIALS AND METHODS: Thirty-one subjects with MS were prospectively scanned before and after intravenous contrast administration at 2 time points, approximately 1 year apart. Fifteen subjects in the cohort were scanned at another time approximately 1 year later. Foci of enhancement were categorized into 4 subtypes: Subarachnoid spread/fill, subarachnoid nodular, vessel wall, and dural foci. We reviewed follow-up scans to determine whether foci changed between time points and then compared persistence with demographic and clinical variables. RESULTS: Persistence ranged from 71% to 100% at 1 year and 73% to 100% at 2 years, depending on the enhancement pattern. Subarachnoid spread/fill and subarachnoid nodular subtypes persisted less often than vessel wall and dural foci. Persistence was not significantly different between those on/off treatment and those with progressive/nonprogressive disease phenotypes. The number of persisting foci was significantly different in subjects with/without increasing Expanded Disability Status Scale scores (median, 12 versus 7.5, P =.04). CONCLUSIONS: Longitudinal persistence of meningeal enhancement on 3D-FLAIR at 7T in MS varies by pattern of enhancement and correlates with worsening disability; however, it is not significantly different in those on/off treatment or in those with progressive/ nonprogressive disease phenotypes. Copyright 2018 American Society of Neuroradiology. All rights reserved.en_US
dc.description.sponsorshipThis study was funded, in part, by grants from EMD Serono and the National Institutes of Health (National Institute of Neurological Disorders and Stroke 1K23NS072366-01A1).en_US
dc.description.urihttps://dx.doi.org/10.3174/ajnr.A5796en_US
dc.language.isoen_USen_US
dc.publisherAmerican Society of Neuroradiologyen_US
dc.relation.ispartofAmerican Journal of Neuroradiology
dc.subjectMultiple Sclerosisen_US
dc.subjectAtrophyen_US
dc.subjectmatter WMen_US
dc.titleLongitudinal persistence of meningeal enhancement on postcontrast 7T 3D-FLAIR MRI in multiple sclerosisen_US
dc.typeArticleen_US
dc.identifier.doi10.3174/ajnr.A5796
dc.identifier.pmid30213813


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