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dc.contributor.authorGadde, U.D.
dc.contributor.authorOh, S.
dc.contributor.authorLillehoj, H.S.
dc.date.accessioned2019-04-29T19:00:58Z
dc.date.available2019-04-29T19:00:58Z
dc.date.issued2018
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85042720673&doi=10.1038%2fs41598-018-22004-6&partnerID=40&md5=7c51f83a2221efe68fde311c63e5bbc7
dc.identifier.urihttp://hdl.handle.net/10713/8914
dc.description.abstractAlthough dietary antibiotic growth promoters have long been used to increase growth performance in commercial food animal production, the biochemical details associated with these effects remain poorly defined. A metabolomics approach was used to characterize and identify the biochemical compounds present in the intestine of broiler chickens fed a standard, unsupplemented diet or a diet supplemented with the antibiotic growth promoters, virginiamycin or bacitracin methylene disalicylate. Compared with unsupplemented controls, the levels of 218 biochemicals were altered (156 increased, 62 decreased) in chickens given the virginiamycin-supplemented diet, while 119 were altered (96 increased, 23 decreased) with the bacitracin-supplemented diet. When compared between antibiotic-supplemented groups, 79 chemicals were altered (43 increased, 36 decreased) in virginiamycin- vs. bacitracin-supplemented chickens. The changes in the levels of intestinal biochemicals provided a distinctive biochemical signature unique to each antibiotic-supplemented group. These biochemical signatures were characterized by increases in the levels of metabolites of amino acids (e.g. 5-hydroxylysine, 2-aminoadipate, 5-hydroxyindoleaceate, 7-hydroxyindole sulfate), fatty acids (e.g. oleate/vaccenate, eicosapentaenoate, 16-hydroxypalmitate, stearate), nucleosides (e.g. inosine, N6-methyladenosine), and vitamins (e.g. nicotinamide). These results provide the framework for future studies to identify natural chemical compounds to improve poultry growth performance without the use of in-feed antibiotics. Copyright 2018 The Author(s).en_US
dc.description.sponsorshipThis work was supported by ARS CRIS Project 8042-32000-107-00D.en_US
dc.description.urihttps://dx.doi.org/10.1038/s41598-018-22004-6en_US
dc.language.isoen_USen_US
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofScientific Reports
dc.subjectbroiler chickensen_US
dc.subjectprobioticsen_US
dc.subjectintestinal morphologyen_US
dc.titleAntibiotic growth promoters virginiamycin and bacitracin methylene disalicylate alter the chicken intestinal metabolomeen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41598-018-22004-6


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