• Login
    View Item 
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Placental H3K27me3 establishes female resilience to prenatal insults

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Author
    Nugent, B.M.
    O'Donnell, C.M.
    Epperson, C.N.
    Date
    2018
    Journal
    Nature Communications
    Publisher
    Nature Publishing Group
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://dx.doi.org/10.1038/s41467-018-04992-1
    Abstract
    Although sex biases in disease presentation are well documented, the mechanisms mediating vulnerability or resilience to diseases are unknown. In utero insults are more likely to produce detrimental health outcomes for males versus females. In our mouse model of prenatal stress, male offspring experience long-term dysregulation of body weight and hypothalamic pituitary adrenal stress axis dysfunction, endophenotypes of male-biased neurodevelopmental disorders. Placental function is critical for healthy fetal development, and we previously showed that sex differences in placental O-linked N-acetylglucosamine transferase (OGT) mediate the effects of prenatal stress on neurodevelopmental programming. Here we show that one mechanism whereby sex differences in OGT confer variation in vulnerability to prenatal insults is by establishing sex-specific trophoblast gene expression patterns and via regulation of the canonically repressive epigenetic modification, H3K27me3. We demonstrate that high levels of H3K27me3 in the female placenta create resilience to the altered hypothalamic programming associated with prenatal stress exposure. Copyright 2018 The Author(s).
    Keyword
    Animals
    Body Weight
    Disease Models, Animal
    Embryo, Mammalian
    Epigenesis, Genetic
    Female
    Fetal Development
    Gene Expression Profiling
    Genes, X-Linked
    Histone Code
    Histones
    Humans
    Hypothalamo-Hypophyseal System
    Male
    Mice
    N-Acetylglucosaminyltransferases
    Placenta
    Pregnancy
    Prenatal Exposure Delayed Effects
    Restraint, Physical
    Sex Factors
    Stress, Physiological
    Trophoblasts
    Show allShow less
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85049404791&doi=10.1038%2fs41467-018-04992-1&partnerID=40&md5=0328137bf198099fbe3c4921c12cdd7f; http://hdl.handle.net/10713/8913
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41467-018-04992-1
    Scopus Count
    Collections
    UMB Open Access Articles

    entitlement

    Related articles

    • Targeted placental deletion of OGT recapitulates the prenatal stress phenotype including hypothalamic mitochondrial dysfunction.
    • Authors: Howerton CL, Bale TL
    • Issue date: 2014 Jul 1
    • Sex-Specific Neurodevelopmental Programming by Placental Insulin Receptors on Stress Reactivity and Sensorimotor Gating.
    • Authors: Bronson SL, Chan JC, Bale TL
    • Issue date: 2017 Jul 15
    • The omniscient placenta: Metabolic and epigenetic regulation of fetal programming.
    • Authors: Nugent BM, Bale TL
    • Issue date: 2015 Oct
    • O-GlcNAc transferase (OGT) as a placental biomarker of maternal stress and reprogramming of CNS gene transcription in development.
    • Authors: Howerton CL, Morgan CP, Fischer DB, Bale TL
    • Issue date: 2013 Mar 26
    • The placenta and neurodevelopment: sex differences in prenatal vulnerability.
    • Authors: Bale TL
    • Issue date: 2016 Dec
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.