Show simple item record

dc.contributor.authorZapata, J.C.
dc.contributor.authorMedina-Moreno, S.
dc.contributor.authorGuzmán-Cardozo, C.
dc.date.accessioned2019-04-29T19:00:58Z
dc.date.available2019-04-29T19:00:58Z
dc.date.issued2018
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85057269997&doi=10.3390%2fpathogens7040084&partnerID=40&md5=8de82521657adf34379a39d5e7e01466
dc.identifier.urihttp://hdl.handle.net/10713/8912
dc.description.abstractIn 2017, the global Coalition for Epidemic Preparedness (CEPI) declared Lassa virus disease to be one of the world's foremost biothreats. In January 2018, World Health Organization experts met to address the Lassa biothreat. It was commonly recognized that the diversity of Lassa virus (LASV) isolated from West African patient samples was far greater than that of the Ebola isolates from the West African epidemic of 2013-2016. Thus, vaccines produced against Lassa virus disease face the added challenge that they must be broadly-protective against a wide variety of LASV. In this review, we discuss what is known about the immune response to Lassa infection. We also discuss the approaches used to make broadly-protective influenza vaccines and how they could be applied to developing broad vaccine coverage against LASV disease. Recent advances in AIDS research are also potentially applicable to the design of broadly-protective medical countermeasures against LASV disease. Copyright 2018 by the authors. Licensee MDPI, Basel, Switzerland.en_US
dc.description.urihttps://dx.doi.org/10.3390/pathogens7040084en_US
dc.language.isoen_USen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofPathogens
dc.subjectB cell anergyen_US
dc.subjectBroadly-neutralizing antibodiesen_US
dc.subjectConformational antigensen_US
dc.subjectConserved antigensen_US
dc.subjectCross-restrictionen_US
dc.subjectDominant and subdominant epitopesen_US
dc.subjectFc-gamma receptorsen_US
dc.subjectFocused immunityen_US
dc.subjectLassa virus disease (LVD)en_US
dc.subjectMimicryen_US
dc.subjectVaccine breadthen_US
dc.titleImproving the breadth of the host's immune response to lassa virusen_US
dc.typeReviewen_US
dc.identifier.doi10.3390/pathogens7040084


This item appears in the following Collection(s)

Show simple item record