Show simple item record

dc.contributor.authorTachedjian, G.
dc.contributor.authorO'Hanlon, D.E.
dc.contributor.authorRavel, J.
dc.date.accessioned2019-04-29T19:00:58Z
dc.date.available2019-04-29T19:00:58Z
dc.date.issued2018
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85042852407&doi=10.1186%2fs40168-018-0418-3&partnerID=40&md5=c3e8b138ffb0c7fe16982e35ef55d3a4
dc.identifier.urihttp://hdl.handle.net/10713/8911
dc.description.abstractIn the cervicovaginal environment, the production of hydrogen peroxide (H2O2) by vaginal Lactobacillus spp. is often mentioned as a critical factor to the in vivo vaginal microbiota antimicrobial properties. We present several lines of evidence that support the implausibility of H2O2 as an "in vivo" contributor to the cervicovaginal milieu antimicrobial properties. An alternative explanation is proposed, supported by previous reports ascribing protective and antimicrobial properties to other factors produced by Lactobacillus spp. capable of generating H2O2. Under this proposal, lactic acid rather than H2O2 plays an important role in the antimicrobial properties of protective vaginal Lactobacillus spp. We hope this commentary will help future research focus on more plausible mechanisms by which vaginal Lactobacillus spp. exert their antimicrobial and beneficial properties, and which have in vivo and translational relevance. Copyright The Author(s). 2018.en_US
dc.description.sponsorshipGT is supported by the National Health and Medical Research Council of Australia (NHMRC) Senior Research Fellowship APP1117748 and NHMRC Project Grant APP1088564. GT gratefully acknowledges the contribution of the Victorian Operational Infrastructure Support Program received by the Burnet Institute. JR is supported by National Institute for Allergy and Infectious Diseases of the National Institutes of Health under award number U19AI084044 and R01NR015495.en_US
dc.description.urihttps://dx.doi.org/10.1186/s40168-018-0418-3en_US
dc.language.isoen_USen_US
dc.publisherBioMed Central Ltd.en_US
dc.relation.ispartofMicrobiome
dc.subjectAnti-Infective Agentsen_US
dc.subjectCell HypoxiaFemaleen_US
dc.subjectGenome, Bacterialen_US
dc.subjectHumansen_US
dc.subjectHydrogen Peroxideen_US
dc.subjectLactic Aciden_US
dc.subjectLactobacillusen_US
dc.subjectMicrobiotaen_US
dc.subjectVaginaen_US
dc.titleThe implausible "in vivo" role of hydrogen peroxide as an antimicrobial factor produced by vaginal microbiotaen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/s40168-018-0418-3
dc.identifier.pmid29409534


This item appears in the following Collection(s)

Show simple item record