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dc.contributor.authorAyoub, L.J.
dc.contributor.authorSeminowicz, D.A.
dc.contributor.authorMoayedi, M.
dc.date.accessioned2019-04-29T19:00:58Z
dc.date.available2019-04-29T19:00:58Z
dc.date.issued2018
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85054190765&doi=10.1016%2fj.nicl.2018.09.018&partnerID=40&md5=027c9856da38553a2747df91fefd841d
dc.identifier.urihttp://hdl.handle.net/10713/8909
dc.description.abstractChronic orofacial pain (COFP) disorders are prevalent and debilitating pain conditions affecting the head, neck and face areas. Neuroimaging studies have reported functional and grey matter abnormalities, but not all the studies have reported consistent findings. Identifying convergent abnormalities across COFPs provides a basis for future hypothesis-driven research aimed at elucidating common CNS mechanisms. Here, we perform three coordinate-based meta-analyses according to PRISMA guidelines to elucidate the central mechanisms of orofacial pain disorders. Specifically, we investigated consistent patterns of: (1) brain function to experimental orofacial pain in healthy subjects, (2) structural and (3) functional brain abnormalities in COFP. We computed our coordinate-based meta-analyses using GingerALE. The experimental pain meta-analysis revealed increased brain activity in bilateral thalami, posterior mid-cingulate cortices, and secondary somatosensory cortices, the right posterior parietal cortex extending to the orofacial region of the right primary somatosensory cortex and the right insula, and decreased activity in the right somatomotor regions. The structural COFP meta-analysis identified consistent higher grey matter volume/concentration in the right ventral thalamus and posterior putamen of COFP patients compared to healthy controls. The functional COFP meta-analysis identified a consistent increase in brain activity in the left medial and posterior thalamus and lesser activity in the left posterior insula in COFP, compared to healthy controls. Overall, these findings provide evidence of brain abnormalities in pain-related regions, namely the thalamus and insula, across different COFP disorders. The convergence of thalamic abnormalities in both structure and function suggest a key role for this region in COFP pathophysiology. Copyright 2018 The Authorsen_US
dc.description.sponsorshipDAS is supported by a grant from NIH/NIDCR under Grant 1R21DE023964 . MM is supported by an NSERC Discovery Grant. M Moayedi acknowledges support from the Bertha Rosenstadt Endowment. We would also like to thank Mr. Erick Patrician and Mr. Steven Lee for their help in reviewing coordinates for the meta-analysis.en_US
dc.description.urihttps://dx.doi.org/10.1016/j.nicl.2018.09.018en_US
dc.language.isoen_USen_US
dc.publisherElsevier Inc.en_US
dc.relation.ispartofNeuroImage: Clinical
dc.subjectfMRIen_US
dc.subjectgrey matter volumeen_US
dc.subjectMRIen_US
dc.subjectorofacial painen_US
dc.subjectplasticityen_US
dc.subjectsMRIen_US
dc.subjecttrigeminalen_US
dc.subjectVBMen_US
dc.subject.meshBrainen_US
dc.subject.meshFacial Painen_US
dc.subject.meshPainen_US
dc.titleA meta-analytic study of experimental and chronic orofacial pain excluding headache disordersen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.nicl.2018.09.018
dc.identifier.pmid30292089


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