Tetrabutylammonium Bromide-Promoted Metal-Free, Efficient, Rapid, and Scalable Synthesis of N-Aryl Amines
PublisherAmerican Chemical Society
MetadataShow full item record
AbstractA rapid, transition metal-free, high-yielding, tetrabutylammonium bromide-promoted method of N-arylation is reported within. The optimized conditions tolerated a wide range of secondary amines and was equally effective with bromo- and chlorobenzene-including substituted aryl halides. The developed method is found to be effective for N-arylation when compared to earlier methods which involve harsh conditions, transition metals, lack of scalability, and long reaction times. Our method utilizes conventional heating only; it is readily scalable; and the products are facile to purify. Copyright 2018 American Chemical Society.
SponsorsThis work was funded by NIMH (R01 107499-01A1).
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85053186003&doi=10.1021%2facsomega.8b01426&partnerID=40&md5=5a4c95c702d22d1b7a291f6a60f97302; http://hdl.handle.net/10713/8877