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dc.contributor.authorMair, D.B.
dc.contributor.authorAmes, H.M.
dc.contributor.authorLi, R.
dc.date.accessioned2019-04-29T19:00:55Z
dc.date.available2019-04-29T19:00:55Z
dc.date.issued2018
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85054889838&doi=10.1091%2fmbc.E18-02-0123&partnerID=40&md5=4f683251f8f770ac0326bf6dc662ef61
dc.identifier.urihttp://hdl.handle.net/10713/8873
dc.description.abstractHigh-grade gliomas are especially difficult tumors to treat due to their invasive behavior. This has led to extensive research focusing on arresting glioma cell migration. Cell migration involves the sensing of a migratory cue, followed by polarization in the direction of the cue, and reorganization of the actin cytoskeleton to allow for a protrusive leading edge and a contractile trailing edge. Transmission of these forces to produce motility also requires adhesive interactions of the cell with the extracellular microenvironment. In glioma cells, transmembrane receptors such as CD44 and integrins bind the cell to the surrounding extracellular matrix that provides a substrate on which the cell can exert the requisite forces for cell motility. These various essential parts of the migratory machinery are potential targets to halt glioma cell invasion. In this review, we discuss the mechanisms of glioma cell migration and how they may be targeted in anti-invasion therapies. Copyright 2018 Mair et al. This article is distributed by The American Society for Cell Biology under license from the author(s).en_US
dc.description.urihttps://dx.doi.org/10.1091/mbc.E18-02-0123en_US
dc.language.isoen_USen_US
dc.publisherAmerican Society for Cell Biologyen_US
dc.relation.ispartofMolecular Biology of the Cell
dc.subjectHermes antigenen_US
dc.subjectintegrinen_US
dc.subjectmembrane receptoren_US
dc.subjecttumor invasionen_US
dc.subjecttumor microenvironmenten_US
dc.titleMechanisms of invasion and motility of high-grade gliomas in the brainen_US
dc.typeReviewen_US
dc.identifier.doi10.1091/mbc.E18-02-0123
dc.identifier.pmid30325290


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