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    Short-Term Plasticity at Olfactory Cortex to Granule Cell Synapses Requires CaV2.1 Activation

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    Author
    Zhou, F.-W.
    Puche, A.C.
    Shipley, M.T.
    Date
    2018
    Journal
    Frontiers in Cellular Neuroscience
    Publisher
    Frontiers Media S.A.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://dx.doi.org/10.3389/fncel.2018.00387
    Abstract
    Output projections of the olfactory bulb (OB) to the olfactory cortex (OCX) and reciprocal feedback projections from OCX provide rapid regulation of OB circuit dynamics and odor processing. Short-term synaptic plasticity (STP), a feature of many synaptic connections in the brain, can modulate the strength of feedback based on preceding network activity. We used light-gated cation channel channelrhodopsin-2 (ChR2) to investigate plasticity of excitatory synaptic currents (EPSCs) evoked at the OCX to granule cell (GC) synapse in the OB. Selective activation of OCX glutamatergic axons/terminals in OB generates strong, frequency-dependent STP in GCs. This plasticity was critically dependent on activation of CaV2.1 channels. As acetylcholine (ACh) modulates CaV2.1 channels in other brain regions and as cholinergic projections from the basal forebrain heavily target the GC layer (GCL) in OB, we investigated whether ACh modulates STP at the OCX→GC synapse. ACh decreases OCX→GC evoked EPSCs, it had no effect on STP. Thus, ACh impact on cortical feedback is independent of CaV2.1-mediated STP. Modulation of OCX feedback to the bulb by modulatory transmitters, such as ACh, or by frequency-dependent STP could regulate the precise balance of excitation and inhibition of GCs. As GCs are a major inhibitory source for OB output neurons, plasticity at the cortical feedback synapse can differentially impact OB output to higher-order networks in situations where ACh inputs are activated or by active sniff sampling of odors. Copyright 2018 Zhou, Puche and Shipley.
    Keyword
    CaV2.1 channels
    Feedback projections
    Light-gated cation channel channelrhodopsin-2
    Olfactory bulb
    Olfactory cortex
    Short-term synaptic plasticity
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056880994&doi=10.3389%2ffncel.2018.00387&partnerID=40&md5=c913bd404a0f22d3090dc295b0fccda2; http://hdl.handle.net/10713/8872
    ae974a485f413a2113503eed53cd6c53
    10.3389/fncel.2018.00387
    Scopus Count
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