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dc.contributor.authorDaya, Michelle
dc.contributor.authorRafaels, Nicholas
dc.contributor.authorBrunetti, Tonya M.
dc.contributor.authorO’Connor, Timothy D.
dc.creatorDaya, M.
dc.date.accessioned2019-04-23T17:05:52Z
dc.date.available2019-04-23T17:05:52Z
dc.date.issued2019-02-20
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85061908861&origin=inward
dc.identifier.urihttp://hdl.handle.net/10713/8865
dc.descriptionAuthor Correction: Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations (Nature Communications, (2019), 10, 1, (880), 10.1038/s41467-019-08469-7)
dc.description.abstractAsthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genome-wide association studies (GWAS) has been inadequate, and true associations in these underrepresented minority groups have been inconclusive. We report the results of a genome-wide meta-analysis from the Consortium on Asthma among African Ancestry Populations (CAAPA; 7009 asthma cases, 7645 controls). We find strong evidence for association at four previously reported asthma loci whose discovery was driven largely by non-African populations, including the chromosome 17q12–q21 locus and the chr12q13 region, a novel (and not previously replicated) asthma locus recently identified by the Trans-National Asthma Genetic Consortium (TAGC). An additional seven loci reported by TAGC show marginal evidence for association in CAAPA. We also identify two novel loci (8p23 and 8q24) that may be specific to asthma risk in African ancestry populations. © 2019, The Author(s).en_US
dc.description.urihttps://dx.doi.org/10.1038/s41467-019-08469-7en_US
dc.description.urihttps://doi.org/10.1038/s41467-019-12158-w
dc.language.isoen_USen_US
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofNature Communicationsen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.meshAfrican Americansen_US
dc.subject.meshAsthmaen_US
dc.subject.meshChromosomes, Human, Pair 12en_US
dc.subject.meshChromosomes, Human, Pair 17en_US
dc.subject.meshChromosomes, Human, Pair 8en_US
dc.subject.meshGenetic Locien_US
dc.subject.meshGenome-Wide Association Studyen_US
dc.subject.meshGenetic Predisposition to Diseaseen_US
dc.subject.meshHispanic Americansen_US
dc.subject.meshUnited Statesen_US
dc.titleAssociation study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populationsen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41467-019-08469-7
dc.identifier.pmid30787307
dc.relation.volume10


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Attribution 3.0 United States
Except where otherwise noted, this item's license is described as Attribution 3.0 United States