Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations
Date
2019-02-20Journal
Nature CommunicationsPublisher
Nature Publishing GroupType
Article
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Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genome-wide association studies (GWAS) has been inadequate, and true associations in these underrepresented minority groups have been inconclusive. We report the results of a genome-wide meta-analysis from the Consortium on Asthma among African Ancestry Populations (CAAPA; 7009 asthma cases, 7645 controls). We find strong evidence for association at four previously reported asthma loci whose discovery was driven largely by non-African populations, including the chromosome 17q12–q21 locus and the chr12q13 region, a novel (and not previously replicated) asthma locus recently identified by the Trans-National Asthma Genetic Consortium (TAGC). An additional seven loci reported by TAGC show marginal evidence for association in CAAPA. We also identify two novel loci (8p23 and 8q24) that may be specific to asthma risk in African ancestry populations. © 2019, The Author(s).Description
Author Correction: Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations (Nature Communications, (2019), 10, 1, (880), 10.1038/s41467-019-08469-7)Rights/Terms
Attribution 3.0 United StatesKeyword
African AmericansAsthma
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 8
Genetic Loci
Genome-Wide Association Study
Genetic Predisposition to Disease
Hispanic Americans
United States
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85061908861&origin=inward; http://hdl.handle.net/10713/8865ae974a485f413a2113503eed53cd6c53
10.1038/s41467-019-08469-7
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