Basic Neuroscience Illuminates Causal Relationship between Sleep and Memory: Translating to Schizophrenia
Date
2018Journal
Schizophrenia BulletinPublisher
Oxford University PressType
Article
Metadata
Show full item recordAbstract
Patients with schizophrenia are often plagued by sleep disturbances that can exacerbate the illness, including potentiating psychosis and cognitive impairments. Cognitive dysfunction is a core feature of schizophrenia with learning and memory being particularly impaired. Sleep disruptions often accompanying the illness and may be key mechanism that contribute to these core dysfunctions. In this special translational neuroscience feature, we highlight the role of sleep in mediating cognitive function, with a special focus on learning and memory. By defining dysfunctional sleep architecture and rhythms in schizophrenia, we focus on the disarray of mechanisms critical to learning and memory and postulate an association between sleep disturbances and cognitive impairments in the disorder. Lastly, we review preclinical models of schizophrenia and highlight exciting translational research that may lead to new therapeutic approaches to alleviating sleep disturbances and effectively improving cognitive function in schizophrenia. ©The Author 2017. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved.Sponsors
The study was supported by the National Institutes of Health (K12 HD43489-14, P50 MH103222, R01 MH094520, and R01 NS102209-01).Identifier to cite or link to this item
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85040828509&doi=10.1093%2fschbul%2fsbx151&partnerID=40&md5=29f12cf3cd912a544346e380cf50b5cb; http://hdl.handle.net/10713/8821ae974a485f413a2113503eed53cd6c53
10.1093/schbul/sbx151
Scopus Count
Collections
Related articles
- Sleep and plasticity in schizophrenia.
- Authors: Sprecher KE, Ferrarelli F, Benca RM
- Issue date: 2015
- Do sleep disturbances contribute to cognitive impairments in schizophrenia spectrum and bipolar disorders?
- Authors: Laskemoen JF, Büchmann C, Barrett EA, Collier-Høegh M, Haatveit B, Vedal TJ, Ueland T, Melle I, Aas M, Simonsen C
- Issue date: 2020 Sep
- Alzheimer's disease and sleep disturbances: a review.
- Authors: Borges CR, Poyares D, Piovezan R, Nitrini R, Brucki S
- Issue date: 2019 Nov
- Sleep Disturbances and Inflammatory Biomarkers in Schizophrenia: Focus on Sex Differences.
- Authors: Lee EE, Ancoli-Israel S, Eyler LT, Tu XM, Palmer BW, Irwin MR, Jeste DV
- Issue date: 2019 Jan
- Memory dysfunction and anxiety-like behavior in a mouse model of chronic sleep disorders.
- Authors: Sakamoto K, Higo-Yamamoto S, Egi Y, Miyazaki K, Oishi K
- Issue date: 2020 Aug 20