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    The gathering storm: Is untreatable typhoid fever on the way?

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    Author
    Levine, Myron M.
    Simon, Raphael
    Date
    2018
    Journal
    mBio
    Publisher
    American Society for Microbiology
    Type
    Note
    
    Metadata
    Show full item record
    See at
    https://dx.doi.org/10.1128/mBio.00482-18
    Abstract
    Klemm et al. (mBio 9:e00105-18, 2018, https://doi.org/10.1128/mBio.00105-18) present comprehensive antibiotic sensitivity patterns and genomic sequence data on Salmonella enterica serovar Typhi blood culture isolates from typhoid fever cases during an epidemic in Pakistan. Microbiologic and genomic data pinpoint the identities and locations of the antimicrobial resistance genes and the outbreak strain's lineage. They propose that Salmonella enterica serovar Typhi be added to the list of bacterial pathogens of public health importance that have become extensively drug resistant (XDR). This paper portends possible dire scenarios for typhoid fever control if XDR strains disseminate globally. Since the outbreak strain is of the H58 haplotype, known for its ability to spread worldwide and displace endemic S. Typhi, this concern is well-founded. The report of Klemm et al. forewarns the global community to address control of typhoid fever more aggressively through prevention, should therapeutic options disappear. This Commentary frames the Klemm et al. findings within a historic perspective. Copyright 2018 Levine and Simon.
    Keyword
    ceftriaxone resistance
    Chloramphenicol
    Typhoid Fever
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85046396485&doi=10.1128%2fmBio.00482-18&partnerID=40&md5=0ec728e213436cc999c7451e4ce6b9d6; http://hdl.handle.net/10713/8801
    ae974a485f413a2113503eed53cd6c53
    10.1128/mBio.00482-18
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