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    Tumor cells versus host immune cells: Whose PD-L1 contributes to PD-1/PD-L1 blockade mediated cancer immunotherapy?

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    Author
    Tang, F.
    Zheng, P.
    Date
    2018
    Journal
    Cell and Bioscience
    Publisher
    BioMed Central Ltd.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://dx.doi.org/10.1186/s13578-018-0232-4
    Abstract
    Antibody blockade of the PD-1/PD-L1 pathway has elicited durable antitumor responses in the therapy of a broad spectrum of cancers. PD-L1 is constitutively expressed in certain tumors and host immune cells, and its expression can be induced or maintained by many factors. The expression of PD-L1 on tumor tissues has been reported to be positively correlated with the efficacy of anti-PD-1/PD-L1 therapy in patients. However, multiple clinical trials indicate that patients with PD-L1-negative tumors also respond to this blockade therapy, which suggests the potential contribution of PD-L1 from host immune cells. Recently, six articles independently evaluated and verified the contributions of PD-L1 from tumor versus non-tumor cells in various mouse tumor models. These studies confirmed that PD-L1 on either tumor cells or host immune cells contributes to tumor escape, and the relative contributions of PD-L1 on these cells seem to be context-dependent. While both tumor- and host-derived PD-L1 can play critical roles in immune suppression, differences in tumor immunogenicity appear to underlie their relative importance. Notably, these reports highlight the essential roles of PD-L1 from host myeloid cells in negatively regulating T cell activation and limiting T cell trafficking. Therefore, comprehensive evaluating the global PD-L1 expression, rather than monitoring PD-L1 expression on tumor cells alone, should be a more accurate way for predicting responses in PD-1/PD-L1 blockade therapy in cancer patients. � 2018 The Author(s).
    Sponsors
    This work is supported by NIH grants (AG036690 and AI64350).
    Keyword
    Cancer immunotherapy
    Host immune cells
    Immune evasion
    Immune therapeutic effect
    PD-1/PD-L1 blockade
    PD-L1
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85046097192&doi=10.1186%2fs13578-018-0232-4&partnerID=40&md5=808d4d6b0e095136fbda4141a6f44f14; http://hdl.handle.net/10713/8796
    ae974a485f413a2113503eed53cd6c53
    10.1186/s13578-018-0232-4
    Scopus Count
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