Frontal cortical control of posterior sensory and association cortices through the claustrum
JournalBrain Structure and Function
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AbstractThe claustrum is a telencephalic gray matter nucleus that is richly interconnected with the neocortex. This structure subserves top-down executive functions that require frontal cortical control of posterior cortical regions. However, functional anatomical support for the claustrum allowing for long-range intercortical communication is lacking. To test this, we performed a channelrhodopsin-assisted long-circuit mapping strategy in mouse brain slices. We find that anterior cingulate cortex input to the claustrum is transiently amplified by claustrum neurons that, in turn, project to parietal association cortex or to primary and secondary visual cortices. Additionally, we observe that claustrum drive of cortical neurons in parietal association cortex is layer-specific, eliciting action potential generation briefly in layers II/III, IV, and VI but not V. These data are the first to provide a functional anatomical substrate through claustrum that may underlie top-down functions, such as executive attention or working memory, providing critical insight to this most interconnected and enigmatic nucleus. � 2018, The Author(s).
Sponsors23 C57BL/6J wildtype mice of both sexes were used. Mice were 10�30�weeks of age at the time of experiments and group-housed with food and water available ad libitum. Mice were on a 12-h light�dark cycle beginning at 0700. This study was performed in accordance with the National Institutes of Health Guide for Care and Use of Laboratory Animals and the University of Maryland, School of Medicine, Animal Care and Use Committee.
KeywordAnterior cingulate cortex
Parietal association cortex
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85045038149&doi=10.1007%2fs00429-018-1661-x&partnerID=40&md5=08071b2efff006b47fe5c3573b431f11; http://hdl.handle.net/10713/8785