• Login
    View Item 
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Clinical and economic impact of statin therapy compliance on hyperlipidemic patients with concomitant CHD risk factors

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Author
    Samant, Navendu Dinanath
    Advisor
    Shaya, Fadia T.
    Date
    2010
    Type
    dissertation
    
    Metadata
    Show full item record
    Abstract
    In cholesterol management, a common and widely used class of drug is 3-hydroxyl-3-methylglutaryl coenzyme A reductase inhibitor (statin). These drugs lower cholesterol by slowing down the production of cholesterol and by increasing the liver's ability to remove LDL cholesterol already in the blood. Statins are well tolerated, and serious side effects such as liver problems, muscle soreness, pain, and weakness are rare. Compliance to prescribed medication is an important component of appropriate pharmacotherapy. Maryland Medicaid managed care (MCO) data were used to examine risk factors of patient non-compliance to statin therapy and its impact on healthcare utilization and the risk of having a new cardiovascular event among patients with hyperlipidemia and one or more CHD risk factors. The sample included Maryland Medicaid MCO patients who were diagnosed with hyperlipidemia and an additional CHD risk factor and were statin drug users. The proportion of patients compliant to statin therapy was 38 percent. The average age of the sample was 50. Over half of the sample was African American (50.69 percent), the rest Caucasian (41.54 percent) and Others (7.77 percent). Results for predictors of statin therapy compliance indicated that age and race had a significant impact on compliance. Although statistically non-significant, compliance was higher among patients with higher Charlson Comorbidity Index (CCI) scores. The probability of being compliant to statin therapy increased with age. African Americans (odds ratio = 0.662, 95 percent CI = 0.580-0.756) and Other race (odds ratio = 0.689, 95 percent CI = 0.549-0.865) groups were less compliant to statin therapy than Caucasians. The cost model indicated that compliant patients did not differ in cardiovascular disease (CVD) related medical costs from semi-compliant or non-compliant patients. The results of the CV risk model indicated that patients who were compliant to statin therapy had lower risk of a cardiovascular event than patients not compliant to statins and the findings were statistically significant. In conclusion, the study did not find significant evidence to prove that compliant patients would have lower CVD related costs. Risk of CV event was lower in compliant patients and was statistically significant. The study was conducted from January 1, 2002 through June 31, 2005. Future studies could examine the impact of compliance over a longer period of time in the Medicaid population.
    Description
    University of Maryland, Baltimore. Pharmaceutical Health Services Research. Ph.D. 2010
    Keyword
    CVD
    statins
    Cost
    Cardiovascular Diseases
    Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Hyperlipidemias
    Medicaid
    Patient Compliance
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/876
    Collections
    Theses and Dissertations All Schools
    Theses and Dissertations School of Pharmacy

    entitlement

     
    DSpace software (copyright © 2002 - 2022)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.