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dc.contributor.authorChapoval, S.P.
dc.date.accessioned2019-04-05T13:55:09Z
dc.date.available2019-04-05T13:55:09Z
dc.date.issued2018
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85057232721&doi=10.1186%2fs10020-018-0014-9&partnerID=40&md5=6c8875c115aabed47e764f13ebc78667
dc.identifier.urihttp://hdl.handle.net/10713/8758
dc.description.abstractSeveral neuronal guidance proteins, known as semaphorin molecules, function in the immune system. This dual tissue performance has led to them being defined as "neuroimmune semaphorins". They have been shown to regulate T cell activation by serving as costimulatory molecules. Similar to classical costimulatory molecules, neuroimmune semaphorins are either constitutively or inducibly expressed on immune cells. In contrast to the classical costimulatory molecule function, the action of neuroimmune semaphorins requires the presence of two signals, the first one provided by TCR/MHC engagement, and the second one provided by B7/CD28 interaction. Thus, neuroimmune semaphorins serve as a "signal three" for immune cell activation and regulate the overall intensity of immune response. The current knowledge on their structures, multiple receptors, specific cell/tissue/organ expression, and distinct functions in different diseases are summarized and discussed in this review.en_US
dc.description.urihttps://dx.doi.org/10.1186/s10020-018-0014-9en_US
dc.language.isoEnglishen_US
dc.publisherNLM (Medline)en_US
dc.relation.ispartofMolecular medicine (Cambridge, Mass.)
dc.subjectCostimulationen_US
dc.subjectImmune responseen_US
dc.subjectInflammationen_US
dc.subjectMolecular targetsen_US
dc.subjectSemaphorinsen_US
dc.titleNeuroimmune semaphorins as costimulatory molecules and beyonden_US
dc.typeReviewen_US
dc.identifier.doi10.1186/s10020-018-0014-9
dc.identifier.pmid30134791


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