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    Merging Orthovoltage X-Ray Minibeams spare the proximal tissues while producing a solid beam at the target

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    Author
    Dilmanian, F.A.
    Krishnan, S.
    McLaughlin, W.E.
    Date
    2019
    Journal
    Scientific Reports
    Publisher
    Nature Publishing Group
    Type
    Article
    
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    See at
    https://dx.doi.org/10.1038/s41598-018-37733-x
    Abstract
    Conventional radiation therapy of brain tumors often produces cognitive deficits, particularly in children. We investigated the potential efficacy of merging Orthovoltage X-ray Minibeams (OXM). It segments the beam into an array of parallel, thin (~0.3 mm), planar beams, called minibeams, which are known from synchrotron x-ray experiments to spare tissues. Furthermore, the slight divergence of the OXM array make the individual minibeams gradually broaden, thus merging with their neighbors at a given tissue depth to produce a solid beam. In this way the proximal tissues, including the cerebral cortex, can be spared. Here we present experimental results with radiochromic films to characterize the method's dosimetry. Furthermore, we present our Monte Carlo simulation results for physical absorbed dose, and a first-order biologic model to predict tissue tolerance. In particular, a 220-kVp orthovoltage beam provides a 5-fold sharper lateral penumbra than a 6-MV x-ray beam. The method can be implemented in arc-scan, which may include volumetric-modulated arc therapy (VMAT). Finally, OXM's low beam energy makes it ideal for tumor-dose enhancement with contrast agents such as iodine or gold nanoparticles, and its low cost, portability, and small room-shielding requirements make it ideal for use in the low-and-middle-income countries. © 2019, The Author(s).
    Keyword
    orthovoltage x-ray minibeams
    Brain Neoplasms--radiotherapy
    Radiation Dose Hyperfractionation
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85061026543&doi=10.1038%2fs41598-018-37733-x&partnerID=40&md5=51230a60f2433e1d50854ee5ab81b5c5; http://hdl.handle.net/10713/8721
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41598-018-37733-x
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