Merging Orthovoltage X-Ray Minibeams spare the proximal tissues while producing a solid beam at the target
PublisherNature Publishing Group
MetadataShow full item record
AbstractConventional radiation therapy of brain tumors often produces cognitive deficits, particularly in children. We investigated the potential efficacy of merging Orthovoltage X-ray Minibeams (OXM). It segments the beam into an array of parallel, thin (~0.3 mm), planar beams, called minibeams, which are known from synchrotron x-ray experiments to spare tissues. Furthermore, the slight divergence of the OXM array make the individual minibeams gradually broaden, thus merging with their neighbors at a given tissue depth to produce a solid beam. In this way the proximal tissues, including the cerebral cortex, can be spared. Here we present experimental results with radiochromic films to characterize the method's dosimetry. Furthermore, we present our Monte Carlo simulation results for physical absorbed dose, and a first-order biologic model to predict tissue tolerance. In particular, a 220-kVp orthovoltage beam provides a 5-fold sharper lateral penumbra than a 6-MV x-ray beam. The method can be implemented in arc-scan, which may include volumetric-modulated arc therapy (VMAT). Finally, OXM's low beam energy makes it ideal for tumor-dose enhancement with contrast agents such as iodine or gold nanoparticles, and its low cost, portability, and small room-shielding requirements make it ideal for use in the low-and-middle-income countries. © 2019, The Author(s).
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85061026543&doi=10.1038%2fs41598-018-37733-x&partnerID=40&md5=51230a60f2433e1d50854ee5ab81b5c5; http://hdl.handle.net/10713/8721
- Interleaved carbon minibeams: an experimental radiosurgery method with clinical potential.
- Authors: Dilmanian FA, Rusek A, Fois GR, Olschowka J, Desnoyers NR, Park JY, Dioszegi I, Dane B, Wang R, Tomasi D, Lee H, Hurley SD, Coyle PK, Meek AG, O'Banion MK
- Issue date: 2012 Oct 1
- Treatment plans optimization for contrast-enhanced synchrotron stereotactic radiotherapy.
- Authors: Edouard M, Broggio D, Prezado Y, Estève F, Elleaume H, Adam JF
- Issue date: 2010 Jun
- Charged Particle Therapy with Mini-Segmented Beams.
- Authors: Dilmanian FA, Eley JG, Rusek A, Krishnan S
- Issue date: 2015
- Minibeam therapy with protons and light ions: physical feasibility and potential to reduce radiation side effects and to facilitate hypofractionation.
- Authors: Dilmanian FA, Eley JG, Krishnan S
- Issue date: 2015 Jun 1
- Design of a modulated orthovoltage stereotactic radiosurgery system.
- Authors: Fagerstrom JM, Bender ET, Lawless MJ, Culberson WS
- Issue date: 2017 Jul