The Evolving Facets of Bacterial Vaginosis: Implications for HIV Transmission
JournalAIDS Research and Human Retroviruses
PublisherMary Ann Liebert Inc.
MetadataShow full item record
AbstractBacterial vaginosis (BV) is a common yet poorly understood vaginal condition that has become a major focus of HIV transmission and immunology research. Varied terminologies are used by clinicians and researchers to describe microbial communities that reside in the female reproductive tract (FRT), which is driven, in part, by microbial genetic and metabolic complexity, evolving diagnostic and molecular techniques, and multidisciplinary perspectives of clinicians, epidemiologists, microbiologists, and immunologists who all appreciate the scientific importance of understanding mechanisms that underlie BV. This Perspectives article aims to clarify the varied terms used to describe the cervicovaginal microbiota and its "nonoptimal" state, under the overarching term of BV. The ultimate goal is to move toward language standardization in future literature that facilitates a better understanding of the impact of BV on FRT immunology and risk of sexually transmitted infections, including HIV. © Lyle R. McKinnon et al. 2019; Published by Mary Ann Liebert, Inc. 2019.
SponsorsA.D.B. and L.R.M. are funded by the Canadian Institutes of Health Research (CIHR) grant TMI-138658. L.R.M. is supported by a CIHR New Investigator award and A.D.B. by the CIHR New Investigator in HIV award NIH-15404. R.K. is funded by CIHR grant PJT-156123. C.K. is funded by an Ontario HIV Treatment Network Applied HIV Chair award and operating grants and an HIV Team grant from CIHR. J.R. was supported by the National Institute for Allergy and Infectious Diseases of the National Institutes of Health under award number U19AI084044. G.T. is funded by the National Health and Medical Research Council of Australia Senior Research Fellowship GNT1117748. G.T. gratefully acknowledges the contribution of the Victorian Operational Infrastructure Support Program received by the Burnet Institute.
female reproductive tract
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85062412846&doi=10.1089%2faid.2018.0304&partnerID=40&md5=ef41b861ea1e9f02ef360c33971fb3e6; http://hdl.handle.net/10713/8707