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dc.contributor.authorBuchwald, A.G.*
dc.contributor.authorTamboura, B.*
dc.contributor.authorHaidara, F.C.*
dc.date.accessioned2019-03-29T14:47:36Z
dc.date.available2019-03-29T14:47:36Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85059795515&doi=10.4269%2fajtmh.18-0450&partnerID=40&md5=8883de57e5bc2fe06b9c37d454bc32a9
dc.identifier.urihttp://hdl.handle.net/10713/8681
dc.description.abstractInfluenza transmission is increased among household contacts. Vaccination decreases transmission; however it is unclear how vaccinating a single individual alters disease risk among household contacts, particularly in regions with low vaccination coverage. Pregnant women were randomized to influenza or control vaccination. Households were visited weekly until infants born to enrolled women reached 6 months. Household contacts younger than 5 years were tested for laboratory-confirmed influenza (LCI). Incidence of LCI and rate ratios (RtR) comparing incidence between vaccine groups were calculated. The secondary infection rate (SIR) was calculated for households where LCI was detected. The H1N1 strain in the vaccine was a match for circulating H1N1 during the study, thus, all analyses were performed for H1N1-LCI and any LCI. A total of 5,345 household contacts younger than 5 years followed for a mean of 228 days (standard deviation [SD] = 45 days) experienced 2,957 influenza-like illness episodes. Incidence of any LCI and H1N1-LCI was 23 (N = 276) and 7.3 per 100,000 days (N = 89), respectively. Household contacts of women who received influenza vaccine had fewer LCI (RtR = 0.90; 95% CI: 0.71, 1.14) and fewer H1N1-LCI (RtR = 0.73; 95% CI: 0.48, 1.11) episodes than contacts in control households. Incidence of LCI and household SIR were low in households of women enrolled in an influenza vaccine trial in Mali. Although low incidence made statistical significance difficult to detect, there was a trend for decreased rates of H1N1-LCI in households where a pregnant mother received influenza vaccination. Copyright 2019 by The American Society of Tropical Medicine and Hygiene.en_US
dc.description.sponsorshipFinancial support: This study was funded by the Bill & Melinda Gates Foundation (grant OPP1002744). Sanofi Pasteur provided the vaccines for this trial.en_US
dc.description.urihttps://dx.doi.org/10.4269/ajtmh.18-0450en_US
dc.language.isoen_USen_US
dc.publisherAmerican Society of Tropical Medicine and Hygieneen_US
dc.relation.ispartofAmerican Journal of Tropical Medicine and Hygiene
dc.subjecthousehold transmissionen_US
dc.subject.meshInfluenza, Human--prevention & controlen_US
dc.subject.meshInfluenza, Human--transmissionen_US
dc.subject.meshMalien_US
dc.subject.meshMothersen_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshInfanten_US
dc.titleMaternal influenza vaccination and the risk of laboratory-confirmed influenza among household contacts under the age of five in Malien_US
dc.typeArticleen_US
dc.identifier.doi10.4269/ajtmh.18-0450
dc.identifier.pmid30526742


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