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dc.contributor.authorChi, M.
dc.contributor.authorQi, M.
dc.contributor.authorLan, A.
dc.date.accessioned2019-03-29T14:47:36Z
dc.date.available2019-03-29T14:47:36Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85060028770&doi=10.3390%2fijms20020278&partnerID=40&md5=e7fe3a4d96e881d76bd289af2096407c
dc.identifier.urihttp://hdl.handle.net/10713/8679
dc.description.abstractPeriodontitis is a common infectious disease characterized by loss of tooth-supporting structures, which eventually leads to tooth loss. The heavy burden of periodontal disease and its negative consequence on the patient's quality of life indicate a strong need for developing effective therapies. According to the World Health Organization, 10-15% of the global population suffers from severe periodontitis. Advances in understanding the etiology, epidemiology and microbiology of periodontal pocket flora have called for antibacterial therapeutic strategies for periodontitis treatment. Currently, antimicrobial strategies combining with polymer science have attracted tremendous interest in the last decade. This review focuses on the state of the art of antibacterial polymer application against periodontal pathogens and biofilms. The first part focuses on the different polymeric materials serving as antibacterial agents, drug carriers and periodontal barrier membranes to inhibit periodontal pathogens. The second part reviews cutting-edge research on the synthesis and evaluation of a new generation of bioactive dental polymers for Class-V restorations with therapeutic effects. They possess antibacterial, acid-reduction, protein-repellent, and remineralization capabilities. In addition, the antibacterial photodynamic therapy with polymeric materials against periodontal pathogens and biofilms is also briefly described in the third part. These novel bioactive and therapeutic polymeric materials and treatment methods have great potential to inhibit periodontitis and protect tooth structures. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.en_US
dc.description.sponsorshipThis study was financially supported by Natural Science Foundation of China NSFC 81400487 (L.W.), 61775080 (B.D.), and 81671032 (J.W.); China Postdoctoral Science Foundation 2015M581405 and 2017T100213 (L.W.); "The 13th Five-Year Plan" Science Foundation of Education Board Jilin Province JJKH20180235KJ (L.W.); Health Department Research Projects in Jilin Province 2016Q032 (L.W.) and 20165074 (C.L.); a seed grant (H.X.) from the University of Maryland Baltimore; and a bridge fund (HX) from the University of Maryland School of Dentistry.en_US
dc.description.urihttps://dx.doi.org/10.3390/ijms20020278en_US
dc.language.isoen_USen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.subjectAntibacterialen_US
dc.subjectDrug deliveryen_US
dc.subjectPeriodontal biofilmsen_US
dc.subjectPeriodontitisen_US
dc.subjectPolymersen_US
dc.titleNovel bioactive and therapeutic dental polymeric materials to inhibit periodontal pathogens and biofilmsen_US
dc.typeReviewen_US
dc.identifier.doi10.3390/ijms20020278
dc.identifier.pmid30641958


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