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dc.contributor.authorKaiser, A.
dc.contributor.authorEley, J.G.
dc.contributor.authorOnyeuku, N.E.
dc.date.accessioned2019-03-29T14:47:35Z
dc.date.available2019-03-29T14:47:35Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85062057485&doi=10.3791%2f58372&partnerID=40&md5=85f1265caa67747906e28953f2db532d
dc.identifier.urihttp://hdl.handle.net/10713/8677
dc.description.abstractRadiation therapy is a frequently used modality for the treatment of solid cancers. Although the mechanisms of cell kill are similar for all forms of radiation, the in vivo properties of photon and proton beams differ greatly and maybe exploited to optimize clinical outcomes. In particular, proton particles lose energy in a predictable manner as they pass through the body. This property is used clinically to control the depth at which the proton beam is terminated, and to limit radiation dose beyond the target region. This strategy can allow for substantial reductions in radiation dose to normal tissues located just beyond a tumor target. However, the degradation of proton energy in the body remains highly sensitive to tissue density. As a consequence, any changes in tissue density during the course of treatment may significantly alter proton dosimetry. Such changes may occur through alterations in body weight, respiration, or bowel filling/gas, and may result in unfavorable dose deposition. In this manuscript, we provide a detailed method for the delivery of proton therapy using both passive scatter and pencil beam scanning techniques for prostate cancer. Although the described procedure directly pertains to prostate cancer patients, the method may be adapted and applied for the treatment of virtually all solid tumors. Our aim is to equip readers with a better understanding of proton therapy delivery and outcomes in order to facilitate the appropriate integration of this modality during cancer therapy.en_US
dc.description.urihttps://dx.doi.org/10.3791/58372en_US
dc.language.isoen_USen_US
dc.publisherJoVEen_US
dc.relation.ispartofJournal of visualized experiments : JoVE
dc.titleProton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignanciesen_US
dc.typeArticleen_US
dc.identifier.doi10.3791/58372
dc.identifier.pmid30799838


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