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    Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

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    Author
    Kaiser, A.
    Eley, J.G.
    Onyeuku, N.E.
    Date
    2019
    Journal
    Journal of visualized experiments : JoVE
    Publisher
    JoVE
    Type
    Article
    
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    Show full item record
    See at
    https://dx.doi.org/10.3791/58372
    Abstract
    Radiation therapy is a frequently used modality for the treatment of solid cancers. Although the mechanisms of cell kill are similar for all forms of radiation, the in vivo properties of photon and proton beams differ greatly and maybe exploited to optimize clinical outcomes. In particular, proton particles lose energy in a predictable manner as they pass through the body. This property is used clinically to control the depth at which the proton beam is terminated, and to limit radiation dose beyond the target region. This strategy can allow for substantial reductions in radiation dose to normal tissues located just beyond a tumor target. However, the degradation of proton energy in the body remains highly sensitive to tissue density. As a consequence, any changes in tissue density during the course of treatment may significantly alter proton dosimetry. Such changes may occur through alterations in body weight, respiration, or bowel filling/gas, and may result in unfavorable dose deposition. In this manuscript, we provide a detailed method for the delivery of proton therapy using both passive scatter and pencil beam scanning techniques for prostate cancer. Although the described procedure directly pertains to prostate cancer patients, the method may be adapted and applied for the treatment of virtually all solid tumors. Our aim is to equip readers with a better understanding of proton therapy delivery and outcomes in order to facilitate the appropriate integration of this modality during cancer therapy.
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    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062057485&doi=10.3791%2f58372&partnerID=40&md5=85f1265caa67747906e28953f2db532d; http://hdl.handle.net/10713/8677
    ae974a485f413a2113503eed53cd6c53
    10.3791/58372
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