• Login
    View Item 
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Two functionally redundant sources of retinoic acid secure spermatogonia differentiation in the seminiferous epithelium

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Author
    Teletin, M.
    Vernet, N.
    Yu, J.
    Date
    2019
    Journal
    Development (Cambridge)
    Publisher
    Company of Biologists Ltd
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://dx.doi.org/10.1242/dev.170225
    Abstract
    In mammals, all-trans retinoic acid (ATRA) is instrumental to spermatogenesis. It is synthesized by two retinaldehyde dehydrogenases (RALDH) present in both Sertoli cells (SCs) and germ cells (GCs). In order to determine the relative contributions of each source of ATRA, we have generated mice lacking all RALDH activities in the seminiferous epithelium (SE). We show that both the SC-and GC-derived sources of ATRA cooperate to initiate and propagate spermatogenetic waves at puberty. In adults, they exert redundant functions and, against all expectations, the GC-derived source does not perform any specific roles despite contributing to two-thirds of the total amount of ATRA present in the testis. The production from SCs is sufficient to maintain the periodic expression of genes in SCs, as well and the cycle and wave of the SE, which account for the steady production of spermatozoa. The production from SCs is also specifically required for spermiation. Importantly, our study shows that spermatogonia differentiation depends upon the ATRA synthesized by RALDH inside the SE, whereas initiation of meiosis and expression of STRA8 by spermatocytes can occur without ATRA. © 2019. Published by The Company of Biologists Ltd.
    Keyword
    Aldh8a1 knockout
    Immunohistochemistry
    Lgals1
    Puberty
    Spermatogenesis
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85059500488&doi=10.1242%2fdev.170225&partnerID=40&md5=176925a74a78cdcd8706891b4b432eb4; http://hdl.handle.net/10713/8650
    ae974a485f413a2113503eed53cd6c53
    10.1242/dev.170225
    Scopus Count
    Collections
    UMB Open Access Articles

    entitlement

    Related articles

    • Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis.
    • Authors: Raverdeau M, Gely-Pernot A, Féret B, Dennefeld C, Benoit G, Davidson I, Chambon P, Mark M, Ghyselinck NB
    • Issue date: 2012 Oct 9
    • Germ Cell-Specific Retinoic Acid Receptor α Functions in Germ Cell Organization, Meiotic Integrity, and Spermatogonia.
    • Authors: Peer NR, Law SM, Murdoch B, Goulding EH, Eddy EM, Kim K
    • Issue date: 2018 Sep 1
    • Stage-specific changes in GDNF expression by rat Sertoli cells: a possible regulator of the replication and differentiation of stem spermatogonia.
    • Authors: Johnston DS, Olivas E, DiCandeloro P, Wright WW
    • Issue date: 2011 Oct
    • Retinoic acid metabolism links the periodical differentiation of germ cells with the cycle of Sertoli cells in mouse seminiferous epithelium.
    • Authors: Sugimoto R, Nabeshima Y, Yoshida S
    • Issue date: 2012 Jan-Feb
    • Cellular and molecular basis for the action of retinoic acid in spermatogenesis.
    • Authors: Griswold MD
    • Issue date: 2022 Nov 1
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.