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dc.contributor.authorTaraban, M.B.
dc.contributor.authorDeredge, D.J.
dc.contributor.authorSmith, M.E.
dc.date.accessioned2019-03-29T14:47:33Z
dc.date.available2019-03-29T14:47:33Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85060292232&doi=10.1039%2fC8RA08795D&partnerID=40&md5=5f45acb6ab47a1f8b315f22a8fe98cc5
dc.identifier.urihttp://hdl.handle.net/10713/8649
dc.description.abstractUnlike many known amphiphiles, the fluorinated amphiphilic dendrimer studied in this work demonstrated a concentration-dependent conformational transition rather than micellization or assembly. Hydrophobic and hydrophilic interactions with water were suggested as the most probable driving force of this transition. This assumption was consistent with the observed 19F chemical shift changes of the dendrimer compared to a known micelle-forming fluorinated amphiphile. Since water is an important factor in the process, trends of the concentration-dependent changes in water proton transverse relaxation rate served as an indicator of structural changes and/or supramolecular assembly. The conformational transition process was also confirmed by ion-mobility mass-spectrometry. We suggested that structural features, namely, steric hindrances, prevented the micellization/assembly of the dendrimer of this study. This conclusion might inform the approach to develop novel unconventional amphiphiles. ©The Royal Society of Chemistry.en_US
dc.description.sponsorshipEarly phase of this work was supported by an NSF grant (CBET 1133908). Mass-spectrometry experiments were supported in part by the University of Maryland Baltimore, School of Pharmacy Mass Spectrometry Center (SOP1841-IQB2014). Financial support from the University of Maryland, Baltimore and the University of Maryland, College Park seed grant is gratefully acknowledged.en_US
dc.description.urihttps://dx.doi.org/10.1039/C8RA08795Den_US
dc.language.isoen_USen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.ispartofRSC Advances
dc.subjectflourinated amphiphilic dendrimeren_US
dc.subjectconformational transitionen_US
dc.subjectsupramolecular assemblyen_US
dc.subject.meshSurface-Active Agentsen_US
dc.titleConformational transition of a non-associative fluorinated amphiphile in aqueous solution. II. Conformational transition vs. supramolecular assemblyen_US
dc.typeArticleen_US
dc.identifier.doi10.1039/C8RA08795D


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