Conformational transition of a non-associative fluorinated amphiphile in aqueous solution. II. Conformational transition vs. supramolecular assembly
PublisherRoyal Society of Chemistry
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AbstractUnlike many known amphiphiles, the fluorinated amphiphilic dendrimer studied in this work demonstrated a concentration-dependent conformational transition rather than micellization or assembly. Hydrophobic and hydrophilic interactions with water were suggested as the most probable driving force of this transition. This assumption was consistent with the observed 19F chemical shift changes of the dendrimer compared to a known micelle-forming fluorinated amphiphile. Since water is an important factor in the process, trends of the concentration-dependent changes in water proton transverse relaxation rate served as an indicator of structural changes and/or supramolecular assembly. The conformational transition process was also confirmed by ion-mobility mass-spectrometry. We suggested that structural features, namely, steric hindrances, prevented the micellization/assembly of the dendrimer of this study. This conclusion might inform the approach to develop novel unconventional amphiphiles. ©The Royal Society of Chemistry.
SponsorsEarly phase of this work was supported by an NSF grant (CBET 1133908). Mass-spectrometry experiments were supported in part by the University of Maryland Baltimore, School of Pharmacy Mass Spectrometry Center (SOP1841-IQB2014). Financial support from the University of Maryland, Baltimore and the University of Maryland, College Park seed grant is gratefully acknowledged.
Keywordflourinated amphiphilic dendrimer
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85060292232&doi=10.1039%2fC8RA08795D&partnerID=40&md5=5f45acb6ab47a1f8b315f22a8fe98cc5; http://hdl.handle.net/10713/8649