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dc.contributor.authorBavisotto, C.C.
dc.contributor.authorScalia, F.
dc.contributor.authorGammazza, A.M.
dc.date.accessioned2019-03-29T14:47:33Z
dc.date.available2019-03-29T14:47:33Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85060370447&doi=10.3390%2fijms20020434&partnerID=40&md5=68417792881e4aa9adefbac88c116d01
dc.identifier.urihttp://hdl.handle.net/10713/8647
dc.description.abstractExtracellular vesicles (EVs), including exosomes, are membranous particles released by cells into the extracellular space. They are involved in cell differentiation, tissue homeostasis, and organ remodelling in virtually all tissues, including the central nervous system (CNS). They are secreted by a range of cell types and via blood reaching other cells whose functioning they can modify because they transport and deliver active molecules, such as proteins of various types and functions, lipids, DNA, and miRNAs. Since they are relatively easy to isolate, exosomes can be characterized, and their composition elucidated and manipulated by bioengineering techniques. Consequently, exosomes appear as promising theranostics elements, applicable to accurately diagnosing pathological conditions, and assessing prognosis and response to treatment in a variety of disorders. Likewise, the characteristics and manageability of exosomes make them potential candidates for delivering selected molecules, e.g., therapeutic drugs, to specific target tissues. All these possible applications are pertinent to research in neurophysiology, as well as to the study of neurological disorders, including CNS tumors, and autoimmune and neurodegenerative diseases. In this brief review, we discuss what is known about the role and potential future applications of exosomes in the nervous system and its diseases, focusing on cell-cell communication in physiology and pathology. ©2019 by the authors. Licensee MDPI, Basel, Switzerland.en_US
dc.description.urihttps://dx.doi.org/10.3390/ijms20020434en_US
dc.language.isoen_USen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.subjectcell-cell interactionen_US
dc.subjectneurological diseasesen_US
dc.subjecttheranostics toolsen_US
dc.subject.meshBiomarkersen_US
dc.subject.meshCentral Nervous Systemen_US
dc.subject.meshExosomesen_US
dc.subject.meshExtracellular Vesiclesen_US
dc.subject.meshNervous Systemen_US
dc.titleExtracellular vesicle-mediated cell-cell communication in the nervous system: Focus on neurological diseasesen_US
dc.typeReviewen_US
dc.identifier.doi10.3390/ijms20020434
dc.identifier.pmid30669512


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