• Login
    View Item 
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Modeling Epidermal Growth Factor Inhibitor-mediated Enhancement of Photodynamic Therapy Efficacy Using 3D Mesothelioma Cell Culture

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Author
    Cramer, G.
    Shin, M.
    Hagan, S.
    Date
    2019
    Journal
    Photochemistry and Photobiology
    Publisher
    John Wiley & Sons
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://dx.doi.org/10.1111/php.13067
    Abstract
    We have demonstrated that lung-sparing surgery with intraoperative photodynamic therapy (PDT) achieves remarkably extended survival for patients with malignant pleural mesothelioma (MPM). Nevertheless, most patients treated using this approach experience local recurrence, so it is essential to identify ways to enhance tumor response. We previously reported that PDT transiently activates EGFR/STAT3 in lung and ovarian cancer cells and inhibiting EGFR via erlotinib can increase PDT sensitivity. Additionally, we have seen higher EGFR expression associating with worse outcomes after Photofrin-mediated PDT for MPM, and the extensive desmoplastic reaction associated with MPM influences tumor phenotype and therapeutic response. Since extracellular matrix (ECM) proteins accrued during stroma development can alter EGF signaling within tumors, we have characterized novel 3D models of MPM to determine their response to erlotinib combined with Photofrin-PDT. Our MPM cell lines formed a range of acinar phenotypes when grown on ECM gels, recapitulating the locally invasive phenotype of MPM in pleura and endothoracic fascia. Using these models, we confirmed that EGFR inhibition increases PDT cytotoxicity. Together with emerging evidence that EGFR inhibition may improve survival of lung cancer patients through immunologic and direct cell killing mechanisms, these results suggest erlotinib-enhanced PDT may significantly improve outcomes for MPM patients. © 2018 The American Society of Photobiology
    Sponsors
    Acknowledgements: This work has been supported in part by NIH/NCI P01-CA087971 and the Penn Translational Centers for Excellence in Mesothelioma Research and Radiation Oncology.
    Keyword
    ErbB Receptors--antagonists & inhibitors
    Erlotinib Hydrochloride--therapteutic use
    Lung
    Mesothelioma--therapy
    Photochemotherapy
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85059621854&doi=10.1111%2fphp.13067&partnerID=40&md5=5992c12491c58562b06fde13d1e6d745; http://hdl.handle.net/10713/8635
    ae974a485f413a2113503eed53cd6c53
    10.1111/php.13067
    Scopus Count
    Collections
    UMB Open Access Articles

    entitlement

    Related articles

    • Preclinical investigation of folate receptor-targeted nanoparticles for photodynamic therapy of malignant pleural mesothelioma.
    • Authors: Kato T, Jin CS, Lee D, Ujiie H, Fujino K, Hu HP, Wada H, Wu L, Chen J, Weersink RA, Kanno H, Hatanaka Y, Hatanaka KC, Kaga K, Matsui Y, Matsuno Y, De Perrot M, Wilson BC, Zheng G, Yasufuku K
    • Issue date: 2018 Nov
    • Phase III randomized trial of surgery with or without intraoperative photodynamic therapy and postoperative immunochemotherapy for malignant pleural mesothelioma.
    • Authors: Pass HI, Temeck BK, Kranda K, Thomas G, Russo A, Smith P, Friauf W, Steinberg SM
    • Issue date: 1997 Dec
    • Low-dose photodynamic therapy promotes a cytotoxic immunological response in a murine model of pleural mesothelioma.
    • Authors: Cavin S, Gkasti A, Faget J, Hao Y, Letovanec I, Reichenbach M, Gonzalez M, Krueger T, Dyson PJ, Meylan E, Perentes JY
    • Issue date: 2020 Oct 1
    • Inhibition of epidermal growth factor receptor signaling in malignant pleural mesothelioma.
    • Authors: Jänne PA, Taffaro ML, Salgia R, Johnson BE
    • Issue date: 2002 Sep 15
    • Photodynamic therapy for lung cancer and malignant pleural mesothelioma.
    • Authors: Simone CB 2nd, Cengel KA
    • Issue date: 2014 Dec
    DSpace software (copyright © 2002 - 2022)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.