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dc.contributor.authorDhall, S.
dc.contributor.authorCoksaygan, T.
dc.contributor.authorHoffman, T.
dc.date.accessioned2019-03-29T14:47:32Z
dc.date.available2019-03-29T14:47:32Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85054438072&doi=10.1016%2fj.bioactmat.2018.09.002&partnerID=40&md5=161d05acc83a4408bd7f597ad67f72a0
dc.identifier.urihttp://hdl.handle.net/10713/8631
dc.description.abstractPost-operative adhesions, a common complication of surgery, cause pain, impair organ functionality, and often require additional surgical interventions. Control of inflammation, protection of injured tissue, and rapid tissue repair are critical for adhesion prevention. Adhesion barriers are biomaterials used to prevent adhesions by physical separation of opposing injured tissues. Current adhesion barriers have poor anti-inflammatory and tissue regenerative properties. Umbilical cord tissue (UT), a part of the placenta, is inherently soft, conforming, biocompatible, and biodegradable, with antimicrobial, anti-inflammatory, and antifibrotic properties, making it an attractive alternative to currently available adhesion barriers. While use of fresh tissue is preferable, availability and short storage time limit its clinical use. A viable cryopreserved UT (vCUT) "point of care" allograft has recently become available. vCUT retains the extracellular matrix, growth factors, and native viable cells with the added advantage of a long shelf life at −80 ° C. In this study, vCUT's anti-adhesion property was evaluated in a rabbit abdominal adhesion model. The cecum was abraded on two opposing sides, and vCUT was sutured to the abdominal wall on the treatment side; whereas the contralateral side of the abdomen served as an internal untreated control. Gross and histological evaluation was performed at 7, 28, and 67 days post-surgery. No adhesions were detectable on the vCUT treated side at all time points. Histological scores for adhesion, inflammation, and fibrosis were lower on the vCUT treated side as compared to the control side. In conclusion, the data supports the use of vCUT as an adhesion barrier in surgical procedures. ©2019en_US
dc.description.urihttps://dx.doi.org/10.1016/j.bioactmat.2018.09.002en_US
dc.language.isoen_USen_US
dc.publisherKeAi Communications Co.en_US
dc.relation.ispartofBioactive Materials
dc.subjectAdhesiolysisen_US
dc.subjectCryopreserveden_US
dc.subjectFibrosisen_US
dc.subjectInflammationen_US
dc.subjectPlacentalen_US
dc.subjectPost-surgicalen_US
dc.titleViable cryopreserved umbilical tissue (vCUT) reduces post-operative adhesions in a rabbit abdominal adhesion modelen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.bioactmat.2018.09.002


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