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dc.contributor.authorRivkin, A.
dc.contributor.authorWeinkle, S.H.
dc.contributor.authorHardas, B.
dc.date.accessioned2019-03-29T14:42:05Z
dc.date.available2019-03-29T14:42:05Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85060349606&doi=10.1093%2fasj%2fsjy019&partnerID=40&md5=0a3187cd299eb97f8e5fbf55bf7ebc80
dc.identifier.urihttp://hdl.handle.net/10713/8627
dc.description.abstractBackground: VYC-15L (Juvéderm Volbella XC) is a nonanimal crosslinked hyaluronic acid (HA) gel with lidocaine. Objectives: To evaluate safety and effectiveness of repeat treatment with VYC-15L administered 1 year after treatment for lip and perioral enhancement. Methods: In this prospective multicenter study, 124 subjects with minimal, mild, or moderate lip fullness on the validated 5-point Allergan Lip Fullness Scale (LFS) who received initial/touch-up treatment with VYC-15L received repeat treatment with VYC-15L 1 year after initial treatment. Effectiveness endpoints included LFS responder rates (≥1-point improvement from baseline) and scores on the FACE-Q Satisfaction With Lips and Appraisal of Lip Lines scales at 1 month after repeat treatment. Subjects completed safety diaries for 30 days after repeat treatment. Results: LFS responder rates were 86.2%, 80.3%, and 65.3% at months 1 and 3 and 1 year, respectively, after initial/touch-up treatment. The responder rate improved to 94.3% 1 month after repeat treatment with VYC-15L and required less median volume vs initial/touch-up treatment (1.5 vs 2.6 mL). FACE-Q scores doubled from baseline at 3 months, remained high through 1 year, and doubled from baseline after repeat treatment. At 1 month after repeat treatment, 96.7% and 89.3% of subjects showed improvement over baseline in FACE-Q Satisfaction With Lips and Appraisal of Lip Lines, respectively. Severe injection site responses were less frequent after repeat treatment than initial/touch-up treatment. Conclusions: Repeat treatment with VYC-15L at 1 year was safe and effective for lip and perioral enhancement, and required less product volume to achieve similar effectiveness to initial/touch-up treatment. © 2018 The American Society for Aesthetic Plastic Surgery, Inc.en_US
dc.description.sponsorshipThis study was funded by Allergan plc (Dublin, Ireland). Editorial support for this article was provided by Peloton Advantage (Parsippany, NJ) and was funded by Allergan plc.en_US
dc.description.urihttps://dx.doi.org/10.1093/asj/sjy019en_US
dc.language.isoen_USen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofAesthetic Surgery Journal
dc.subjectJuvéderm Volbella XCen_US
dc.subject.meshCosmetic Techniquesen_US
dc.subject.meshDermatologic Agentsen_US
dc.subject.meshLipen_US
dc.titleSafety and Effectiveness of Repeat Treatment With VYC-15L for Lip and Perioral Enhancement: Results From a Prospective Multicenter Studyen_US
dc.typeArticleen_US
dc.identifier.doi10.1093/asj/sjy019
dc.identifier.pmid29506034


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