Show simple item record

dc.contributor.authorChen, Y.*
dc.contributor.authorZhang, W.*
dc.contributor.authorWu, H.*
dc.date.accessioned2019-03-29T14:42:02Z
dc.date.available2019-03-29T14:42:02Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85061363147&doi=10.1186%2fs13063-019-3212-z&partnerID=40&md5=38bae6336f50b9acde6accac55c611f3
dc.identifier.urihttp://hdl.handle.net/10713/8600
dc.description.abstractBackground: Mild cognitive impairment (MCI) is known as a transitional status between normal cognitive function and Alzheimer's disease (AD). Acupuncture and Chinese herbal medicines (CHMs) are considered to be beneficial to patients with cognitive impairment. However, it is still unknown whether the combination of the two therapies could optimize the therapeutic effect for MCI. This trial is aimed to evaluate the therapeutic effects of acupuncture and the herbal formula Yishen Granule (YSG) for elderly patients with MCI. Methods/design: This is a multi-sited, patient-blinded, randomized controlled trial (RCT). Two hundred and forty eligible patients will be randomly divided into four groups: A. acupuncture with YSG, B. acupuncture with placebo herbal medicine, C. sham acupuncture with YSG or D. sham acupuncture with placebo herbal medicine. Acupuncture treatment will be given twice a week for 8 weeks and then once a week for 4 weeks. The herbal treatment patients will be given granules daily for 12 weeks, 8 weeks of standard-dose followed by 4 weeks of mid-dose. The primary outcome is scored by the Montreal Cognitive Assessment (MoCA). The secondary outcomes will be scored by the Mini-Mental State Examination (MMSE) and event-related potential (ERP). All the assessments will be conducted at baseline, and at the eighth and 12th week after intervention starts. The follow-up assessments will be performed with the MoCA in the 12th, 24th, and 36th weeks after intervention ends. Intention-to-treat (ITT) analysis will be used in this RCT. Discussion: This RCT will provide us information on the effect of treating MCI patients with only acupuncture, herbal formula as well as the combination of both. The additive effect or synergistic effect of acupuncture and Chinese herbal formula will then be analyzed. Trial registration: This trial is registered with ChiCTR-INR-17011569 on 5 June 2017, and has been approved by the Ethics Committee of Shanghai Municipal Hospital of Traditional Chinese Medicine (2017SHL-KY-05). © 2019 The Author(s).en_US
dc.description.sponsorshipThis RCT is funded by the Shanghai Municipal Commission of Health and Family Planning (Grant No. 2015ZB0504).en_US
dc.description.urihttps://dx.doi.org/10.1186/s13063-019-3212-zen_US
dc.language.isoen_USen_US
dc.publisherBioMed Central Ltd.en_US
dc.relation.ispartofTrials
dc.subjectAcupunctureen_US
dc.subjectChinese herbal formulaen_US
dc.subjectMild cognitive impairment (MCI)en_US
dc.subjectProtocolen_US
dc.subjectRandomized controlled trial (RCT)en_US
dc.titleCombination of acupuncture and Chinese herbal formula for elderly adults with mild cognitive impairment: Protocol for a randomized controlled trialen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/s13063-019-3212-z
dc.identifier.pmid30744676


This item appears in the following Collection(s)

Show simple item record