Show simple item record

dc.contributor.authorBalhaddad, A.A.
dc.contributor.authorKansara, A.A.
dc.contributor.authorHidan, D.
dc.date.accessioned2019-03-29T14:42:02Z
dc.date.available2019-03-29T14:42:02Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85058537052&doi=10.1016%2fj.bioactmat.2018.12.002&partnerID=40&md5=f1252c47d22711c9507d2c3c7656d045
dc.identifier.urihttp://hdl.handle.net/10713/8596
dc.description.abstractMillions of people worldwide suffer from a toothache due to tooth cavity, and often permanent tooth loss. Dental caries, also known as tooth decay, is a biofilm-dependent infectious disease that damages teeth by minerals loss and presents a high incidence of clinical restorative polymeric fillings (tooth colored fillings). Until now, restorative polymeric fillings present no bioactivity. The complexity of oral biofilms contributes to the difficulty in developing effective novel dental materials. Nanotechnology has been explored in the development of bioactive dental materials to reduce or modulate the activities of caries-related bacteria. Nano-structured platforms based on calcium phosphate and metallic particles have advanced to impart an anti-caries potential to restorative materials. The bioactivity of these platforms induces prevention of mineral loss of the hard tooth structure and antibacterial activities against carries-related pathogens. It has been suggested that this bioactivity could minimize the incidence of caries around restorations (CARS) and increase the longevity of such filling materials. The last few years witnessed growing numbers of studies on the preparation evaluations of these novel materials. Herein, the caries disease process and the role of pathogenic caries-related biofilm, the increasing incidence of CARS, and the recent efforts employed for incorporation of bioactive nanoparticles in restorative polymer materials as useful strategies for prevention and management of caries-related-bacteria are discussed. We highlight the status of the most advanced and widely explored interaction of nanoparticle-based platforms and calcium phosphate compounds with an eye toward translating the potential of these approaches to the dental clinical reality. © 2018en_US
dc.description.urihttps://dx.doi.org/10.1016/j.bioactmat.2018.12.002en_US
dc.language.isoen_USen_US
dc.publisherKeAi Communications Co.en_US
dc.relation.ispartofBioactive Materials
dc.subjectbioactiveen_US
dc.subject.meshDental Cariesen_US
dc.subject.meshDental Materialsen_US
dc.subject.meshNanoparticlesen_US
dc.titleToward dental caries: Exploring nanoparticle-based platforms and calcium phosphate compounds for dental restorative materialsen_US
dc.typeReviewen_US
dc.identifier.doi10.1016/j.bioactmat.2018.12.002


Files in this item

Thumbnail
Name:
Publisher version

This item appears in the following Collection(s)

Show simple item record