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dc.contributor.authorBanerjee, A.
dc.contributor.authorKulcsar, K.
dc.contributor.authorMisra, V.
dc.date.accessioned2019-03-29T14:42:01Z
dc.date.available2019-03-29T14:42:01Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85059915893&doi=10.3390%2fv11010041&partnerID=40&md5=408f54b8ebb05557b7485025652324f2
dc.identifier.urihttp://hdl.handle.net/10713/8588
dc.description.abstractBats are speculated to be reservoirs of several emerging viruses including coronaviruses (CoVs) that cause serious disease in humans and agricultural animals. These include CoVs that cause severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), porcine epidemic diarrhea (PED) and severe acute diarrhea syndrome (SADS). Bats that are naturally infected or experimentally infected do not demonstrate clinical signs of disease. These observations have allowed researchers to speculate that bats are the likely reservoirs or ancestral hosts for several CoVs. In this review, we follow the CoV outbreaks that are speculated to have originated in bats. We review studies that have allowed researchers to identify unique adaptation in bats that may allow them to harbor CoVs without severe disease. We speculate about future studies that are critical to identify how bats can harbor multiple strains of CoVs and factors that enable these viruses to "jump" from bats to other mammals. We hope that this review will enable readers to identify gaps in knowledge that currently exist and initiate a dialogue amongst bat researchers to share resources to overcome present limitations. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.en_US
dc.description.sponsorshipFunding: This study was funded by Natural Science and Engineering Research Council of Canada's Discovery Grants awarded to K.M. and V.M., a M.G. DeGroote fellowship awarded to A.B., grant R21AI126300 to K.K. and M.F. and grant F32AI136390 to K.K.en_US
dc.description.urihttps://dx.doi.org/10.3390/v11010041en_US
dc.language.isoen_USen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofViruses
dc.subjectbatsen_US
dc.subjectin vitroen_US
dc.subjectin vivoen_US
dc.subject.lcshImmune responseen_US
dc.subject.meshCoronavirusen_US
dc.titleBats and coronavirusesen_US
dc.typeReviewen_US
dc.identifier.doi10.3390/v11010041
dc.identifier.pmid30634396


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