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    Bats and coronaviruses

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    Author
    Banerjee, A.
    Kulcsar, K.
    Misra, V.
    Date
    2019
    Journal
    Viruses
    Publisher
    MDPI AG
    Type
    Review
    
    Metadata
    Show full item record
    See at
    https://dx.doi.org/10.3390/v11010041
    Abstract
    Bats are speculated to be reservoirs of several emerging viruses including coronaviruses (CoVs) that cause serious disease in humans and agricultural animals. These include CoVs that cause severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), porcine epidemic diarrhea (PED) and severe acute diarrhea syndrome (SADS). Bats that are naturally infected or experimentally infected do not demonstrate clinical signs of disease. These observations have allowed researchers to speculate that bats are the likely reservoirs or ancestral hosts for several CoVs. In this review, we follow the CoV outbreaks that are speculated to have originated in bats. We review studies that have allowed researchers to identify unique adaptation in bats that may allow them to harbor CoVs without severe disease. We speculate about future studies that are critical to identify how bats can harbor multiple strains of CoVs and factors that enable these viruses to "jump" from bats to other mammals. We hope that this review will enable readers to identify gaps in knowledge that currently exist and initiate a dialogue amongst bat researchers to share resources to overcome present limitations. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
    Sponsors
    Funding: This study was funded by Natural Science and Engineering Research Council of Canada's Discovery Grants awarded to K.M. and V.M., a M.G. DeGroote fellowship awarded to A.B., grant R21AI126300 to K.K. and M.F. and grant F32AI136390 to K.K.
    Keyword
    bats
    in vitro
    in vivo
    Immune response
    Coronavirus
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85059915893&doi=10.3390%2fv11010041&partnerID=40&md5=408f54b8ebb05557b7485025652324f2; http://hdl.handle.net/10713/8588
    ae974a485f413a2113503eed53cd6c53
    10.3390/v11010041
    Scopus Count
    Collections
    UMB Coronavirus Publications
    UMB Open Access Articles 2019

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