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dc.contributor.authorBrown, C.N.*
dc.contributor.authorGreen, B.D.*
dc.contributor.authorThompson, R.B.*
dc.date.accessioned2019-03-29T14:42:01Z
dc.date.available2019-03-29T14:42:01Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85060064453&doi=10.3390%2fmetabo9010004&partnerID=40&md5=66b52a32269f9d377f444e4840b04b99
dc.identifier.urihttp://hdl.handle.net/10713/8587
dc.description.abstractAge-related macular degeneration (AMD) leads to irreversible visual loss, therefore, early intervention is desirable, but due to its multifactorial nature, diagnosis of early disease might be challenging. Identification of early markers for disease development and progression is key for disease diagnosis. Suitable biomarkers can potentially provide opportunities for clinical intervention at a stage of the disease when irreversible changes are yet to take place. One of the most metabolically active tissues in the human body is the retina, making the use of hypothesis-free techniques, like metabolomics, to measure molecular changes in AMD appealing. Indeed, there is increasing evidence that metabolic dysfunction has an important role in the development and progression of AMD. Therefore, metabolomics appears to be an appropriate platform to investigate disease-associated biomarkers. In this review, we explored what is known about metabolic changes in the retina, in conjunction with the emerging literature in AMD metabolomics research. Methods for metabolic biomarker identification in the eye have also been discussed, including the use of tears, vitreous, and aqueous humor, as well as imaging methods, like fluorescence lifetime imaging, that could be translated into a clinical diagnostic tool with molecular level resolution. © 2019, MDPI AG. All rights reserved.en_US
dc.description.sponsorshipFunding: This review article was supported by a Department for Education PhD studentship to C.N.B. and the Eye-Risk project funded by the European Union's Horizon 2020 research and innovation programme [634479].en_US
dc.description.urihttps://dx.doi.org/10.3390/metabo9010004en_US
dc.language.isoen_USen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofMetabolites
dc.subjectAge-related macular degenerationen_US
dc.subjectBiomarkersen_US
dc.subjectDrusenen_US
dc.subjectMetabolismen_US
dc.subjectMetabolomicsen_US
dc.subjectRetinal pigment epitheliumen_US
dc.titleMetabolomics and age-related macular degenerationen_US
dc.typeReviewen_US
dc.identifier.doi10.3390/metabo9010004


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