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dc.contributor.authorTolbert, W.D.
dc.contributor.authorSherburn, R.T.
dc.contributor.authorVan, V.
dc.date.accessioned2019-03-29T14:42:00Z
dc.date.available2019-03-29T14:42:00Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85060129504&doi=10.3390%2fv11010069&partnerID=40&md5=a6aaebb312ee21296b0083e5e061a53a
dc.identifier.urihttp://hdl.handle.net/10713/8568
dc.description.abstractWhile a number of therapeutic options to control the progression of human immunodeficiency virus (HIV-1) now exist, a broadly effective preventive vaccine is still not available. Through detailed structural analysis of antibodies able to induce potent effector cell activity, a number of Env epitopes have been identified which have the potential to be considered vaccine candidates. These antibodies mainly target the gp120 Cluster A region which is only exposed upon viral binding to the target cell with epitopes becoming available for antibody binding during viral entry and fusion and, therefore, after the effective window for neutralizing antibody activity. This review will discuss recent advances in the structural characterization of these important targets with a special focus on epitopes that are involved in Fc-mediated effector function without direct viral neutralizing activities. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.en_US
dc.description.sponsorshipThis work was supported by NIH grants: NIAID R01 AI116274 and R01 AI129769 to MP, NIAID P01 AI120756 to G.T.en_US
dc.description.urihttps://dx.doi.org/10.3390/v11010069en_US
dc.language.isoen_USen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofViruses
dc.subjectA32en_US
dc.subjectADCCen_US
dc.subjectC11en_US
dc.subjectHIVen_US
dc.subjectStructureen_US
dc.subjectVaccineen_US
dc.titleStructural basis for epitopes in the gp120 cluster a region that invokes potent effector cell activityen_US
dc.typeReviewen_US
dc.identifier.doi10.3390/v11010069
dc.identifier.pmid30654465


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