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    Structural basis for epitopes in the gp120 cluster a region that invokes potent effector cell activity

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    Author
    Tolbert, W.D.
    Sherburn, R.T.
    Van, V.
    Date
    2019
    Journal
    Viruses
    Publisher
    MDPI AG
    Type
    Review
    
    Metadata
    Show full item record
    See at
    https://dx.doi.org/10.3390/v11010069
    Abstract
    While a number of therapeutic options to control the progression of human immunodeficiency virus (HIV-1) now exist, a broadly effective preventive vaccine is still not available. Through detailed structural analysis of antibodies able to induce potent effector cell activity, a number of Env epitopes have been identified which have the potential to be considered vaccine candidates. These antibodies mainly target the gp120 Cluster A region which is only exposed upon viral binding to the target cell with epitopes becoming available for antibody binding during viral entry and fusion and, therefore, after the effective window for neutralizing antibody activity. This review will discuss recent advances in the structural characterization of these important targets with a special focus on epitopes that are involved in Fc-mediated effector function without direct viral neutralizing activities. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
    Sponsors
    This work was supported by NIH grants: NIAID R01 AI116274 and R01 AI129769 to MP, NIAID P01 AI120756 to G.T.
    Keyword
    A32
    ADCC
    C11
    HIV
    Structure
    Vaccine
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85060129504&doi=10.3390%2fv11010069&partnerID=40&md5=a6aaebb312ee21296b0083e5e061a53a; http://hdl.handle.net/10713/8568
    ae974a485f413a2113503eed53cd6c53
    10.3390/v11010069
    Scopus Count
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    UMB Open Access Articles 2019

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