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    Small GTPases and Their Role in Vascular Disease

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    Author
    Flentje, A.
    Kalsi, R.
    Monahan, T.S.
    Date
    2019
    Journal
    International journal of molecular sciences
    Publisher
    MDPI
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://dx.doi.org/10.3390/ijms20040917
    Abstract
    Over eighty million people in the United States have cardiovascular disease that can affect the heart causing myocardial infarction; the carotid arteries causing stroke; and the lower extremities leading to amputation. The treatment for end-stage cardiovascular disease is surgical-either endovascular therapy with balloons and stents-or open reconstruction to reestablish blood flow. All interventions damage or destroy the protective inner lining of the blood vessel-the endothelium. An intact endothelium is essential to provide a protective; antithrombotic lining of a blood vessel. Currently; there are no agents used in the clinical setting that promote reendothelialization. This process requires migration of endothelial cells to the denuded vessel; proliferation of endothelial cells on the denuded vessel surface; and the reconstitution of the tight adherence junctions responsible for the formation of an impermeable surface. These processes are all regulated in part and are dependent on small GTPases. As important as the small GTPases are for reendothelialization, dysregulation of these molecules can result in various vascular pathologies including aneurysm formation, atherosclerosis, diabetes, angiogenesis, and hypertension. A better understanding of the role of small GTPases in endothelial cell migration is essential to the development for novel agents to treat vascular disease.
    Keyword
    cdc42
    migration
    rac1
    restenosis
    RhoA
    small GTPases
    vascular endothelium
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85061978919&doi=10.3390%2fijms20040917&partnerID=40&md5=3ba381b4dcd58428b406681ac8a83cf1; http://hdl.handle.net/10713/8546
    ae974a485f413a2113503eed53cd6c53
    10.3390/ijms20040917
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