• Login
    View Item 
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Neuroimmune semaphorin 4A in cancer angiogenesis and inflammation: A promoter or a suppressor?

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Author
    Iyer, A.S.
    Chapoval, S.P.
    Date
    2019
    Journal
    International Journal of Molecular Sciences
    Publisher
    MDPI AG
    Type
    Review
    
    Metadata
    Show full item record
    See at
    https://dx.doi.org/10.3390/ijms20010124
    Abstract
    Neuroimmune semaphorin 4A (Sema4A), a member of semaphorin family of transmembrane and secreted proteins, is an important regulator of neuronal and immune functions. In the nervous system, Sema4A primarily regulates the functional activity of neurons serving as an axon guidance molecule. In the immune system, Sema4A regulates immune cell activation and function, instructing a fine tuning of the immune response. Recent studies have shown a dysregulation of Sema4A expression in several types of cancer such as hepatocellular carcinoma, colorectal, and breast cancers. Cancers have been associated with abnormal angiogenesis. The function of Sema4A in angiogenesis and cancer is not defined. Recent studies have demonstrated Sema4A expression and function in endothelial cells. However, the results of these studies are controversial as they report either pro-or anti-angiogenic Sema4A effects depending on the experimental settings. In this mini-review, we discuss these findings as well as our data on Sema4A regulation of inflammation and angiogenesis, which both are important pathologic processes underlining tumorigenesis and tumor metastasis. Understanding the role of Sema4A in those processes may guide the development of improved therapeutic treatments for cancer. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
    Sponsors
    Funding: The research was supported by the NIH/NIAID R21AI076736 grant. Svetlana P. Chapoval is supported by the NIH/NIAID R01AI122631 grant and by SemaPlex LLC.
    Keyword
    Angiogenesis
    Cancer
    Inflammation
    Neuroimmune semaphorins
    Plexins
    Sema4A
    VEGF
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85059283294&doi=10.3390%2fijms20010124&partnerID=40&md5=b7e97097f6e75bc0b6aeb0c15b06b415; http://hdl.handle.net/10713/8540
    ae974a485f413a2113503eed53cd6c53
    10.3390/ijms20010124
    Scopus Count
    Collections
    UMB Open Access Articles

    entitlement

    Related articles

    • The role of Sema4A in angiogenesis, immune responses, carcinogenesis, and retinal systems.
    • Authors: Ito D, Kumanogoh A
    • Issue date: 2016 Nov
    • Expression of neuroimmune semaphorins 4A and 4D and their receptors in the lung is enhanced by allergen and vascular endothelial growth factor.
    • Authors: Smith EP, Shanks K, Lipsky MM, DeTolla LJ, Keegan AD, Chapoval SP
    • Issue date: 2011 May 19
    • Semaphorin 4A restricts tumor progression by inhibiting angiogenesis of oral squamous cell carcinoma cells.
    • Authors: Liu XQ, Yao Y, Mu JW, Yang FY
    • Issue date: 2021 Apr
    • Semaphorin 4A exerts a proangiogenic effect by enhancing vascular endothelial growth factor-A expression in macrophages.
    • Authors: Meda C, Molla F, De Pizzol M, Regano D, Maione F, Capano S, Locati M, Mantovani A, Latini R, Bussolino F, Giraudo E
    • Issue date: 2012 Apr 15
    • Semaphorin-4A, an activator for T-cell-mediated immunity, suppresses angiogenesis via Plexin-D1.
    • Authors: Toyofuku T, Yabuki M, Kamei J, Kamei M, Makino N, Kumanogoh A, Hori M
    • Issue date: 2007 Mar 7
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.