Neuroimmune semaphorin 4A in cancer angiogenesis and inflammation: A promoter or a suppressor?
Date
2019Journal
International Journal of Molecular SciencesPublisher
MDPI AGType
Review
Metadata
Show full item recordAbstract
Neuroimmune semaphorin 4A (Sema4A), a member of semaphorin family of transmembrane and secreted proteins, is an important regulator of neuronal and immune functions. In the nervous system, Sema4A primarily regulates the functional activity of neurons serving as an axon guidance molecule. In the immune system, Sema4A regulates immune cell activation and function, instructing a fine tuning of the immune response. Recent studies have shown a dysregulation of Sema4A expression in several types of cancer such as hepatocellular carcinoma, colorectal, and breast cancers. Cancers have been associated with abnormal angiogenesis. The function of Sema4A in angiogenesis and cancer is not defined. Recent studies have demonstrated Sema4A expression and function in endothelial cells. However, the results of these studies are controversial as they report either pro-or anti-angiogenic Sema4A effects depending on the experimental settings. In this mini-review, we discuss these findings as well as our data on Sema4A regulation of inflammation and angiogenesis, which both are important pathologic processes underlining tumorigenesis and tumor metastasis. Understanding the role of Sema4A in those processes may guide the development of improved therapeutic treatments for cancer. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.Sponsors
Funding: The research was supported by the NIH/NIAID R21AI076736 grant. Svetlana P. Chapoval is supported by the NIH/NIAID R01AI122631 grant and by SemaPlex LLC.Identifier to cite or link to this item
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85059283294&doi=10.3390%2fijms20010124&partnerID=40&md5=b7e97097f6e75bc0b6aeb0c15b06b415; http://hdl.handle.net/10713/8540ae974a485f413a2113503eed53cd6c53
10.3390/ijms20010124
Scopus Count
Collections
Related articles
- The role of Sema4A in angiogenesis, immune responses, carcinogenesis, and retinal systems.
- Authors: Ito D, Kumanogoh A
- Issue date: 2016 Nov
- Expression of neuroimmune semaphorins 4A and 4D and their receptors in the lung is enhanced by allergen and vascular endothelial growth factor.
- Authors: Smith EP, Shanks K, Lipsky MM, DeTolla LJ, Keegan AD, Chapoval SP
- Issue date: 2011 May 19
- Semaphorin 4A restricts tumor progression by inhibiting angiogenesis of oral squamous cell carcinoma cells.
- Authors: Liu XQ, Yao Y, Mu JW, Yang FY
- Issue date: 2021 Apr
- Semaphorin 4A exerts a proangiogenic effect by enhancing vascular endothelial growth factor-A expression in macrophages.
- Authors: Meda C, Molla F, De Pizzol M, Regano D, Maione F, Capano S, Locati M, Mantovani A, Latini R, Bussolino F, Giraudo E
- Issue date: 2012 Apr 15
- Semaphorin-4A, an activator for T-cell-mediated immunity, suppresses angiogenesis via Plexin-D1.
- Authors: Toyofuku T, Yabuki M, Kamei J, Kamei M, Makino N, Kumanogoh A, Hori M
- Issue date: 2007 Mar 7