• Rectal Volume and Quality of Life in Prostate Cancer Patients Receiving Pediococcus-Based Probiotics and Radiation Therapy: A Prospective Randomized Trial

      Haskins, C.; Siddiqui, O.M.; Lin, J.Y.; Bentzen, S.M.; Mishra, M.V.; Vujaskovic, Z. (Elsevier, 2021-11)
      Previous research identified Lactobacillus-based probiotic administration significantly reduced median and percent rectal volumes in prostate cancer (PC) patients undergoing daily radiation therapy (RT). However, Lactobacillus is sensitive to the acidic environment in the stomach. Pediococcus-based probiotics are resistant to pH as low as 1.5. We designed a prospective randomized trial to determine if administration of a Pediococcus-based probiotic therapy is feasible in patients undergoing prostate RT. An exploratory aim was to determine if probiotic therapy decreased rectal volumes throughout RT for PC compared to placebo.