Other TitlesEAPA's 2008 Annual World EAP Conference
Addiction Craving and Addiction Memory: Clearing a Path to Recovery
AbstractIn this address, Dr. Paul Earley presents the neurophysiology of an important and often overlooked component of the recovery experience: Addiction Memory. When a patient begins the journey into recovery from an addiction of any kind, effective cravings management is critical for sustaining that recovery. Despite this fact, addiction treatment does not do enough to train addicts and alcoholics how to manage their cravings. Learn about the different sub-types of addiction cravings and new techniques for cravings management. This presentation provides a deeper understanding of how the experience of addiction entrains neural circuits to promote relapse and, most importantly, how to rewire the addicted brain to prevent relapse.
DescriptionThe image on the original recording is not clear but the audio is fine.
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/8367
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The Development of levo-Tetrahydropalmatine as a Treatment for Nicotine AddictionFaison, Shamia; Wang, Jia Bei; 0000-0002-4355-8624 (2015)The negative consequences of nicotine use are well known and documented, however, abstaining from nicotine use and achieving abstinence poses a major challenge for the majority of nicotine users trying to quit. l-Tetrahydropalmatine (l-THP), a compound extracted from the Chinese herb Corydalis, has been used clinically in China for over 40 years as a sedative and analgesic. l-THP has also displayed utility in the treatment of drug addiction, particularly cocaine and heroin addiction. The objective of this dissertation was to investigate if the utility of l-THP could be extended to include treatment of nicotine addiction. As such, the effect of l-THP treatment on abuse-related effects of nicotine was assessed in various behavioral models of nicotine addiction. Once the utility of l-THP was determined, the efficacy of l-THP was tested against varenicline and bupropion, FDA approved treatments for nicotine addiction. To better understand neurochemical changes that occur with l-THP administration, microdialysis experiments were performed where it was found that l-THP interacts with the mesolimbic dopamine system, a prominent pathway of drug addiction. The efficacy of l-THP in the treatment of various models of nicotine addiction and its interaction with the mesolimbic dopamine system make l-THP an attractive compound to study concerning nicotine addiction. Given the long standing safe use of l-THP in China and this new preclinical data, l-THP warrants further study and development for the treatment of nicotine addiction.
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