Show simple item record

dc.contributor.authorAl Dulaijan, Yousif Ali
dc.date.accessioned2018-06-28T13:50:30Z
dc.date.available2018-06-28T13:50:30Z
dc.date.issued2018
dc.identifier.urihttp://hdl.handle.net/10713/8029
dc.descriptionUniversity of Maryland, Baltimore. Biomedical Sciences-Dental School. Ph.D. 2018en_US
dc.description.abstractDental composites are popular for tooth cavity restorations due to their aesthetics, conservative approach, and direct-filling abilities. However, composite restorations have limited lifetime due to several limitations, including secondary caries, fracture, minimal abrasion and wear resistance and higher marginal leakage. Indeed, secondary caries is the primary reason for composite restoration failure. Besides, several studies have shown that conventional dental composites accumulate more biofilms/plaque when compared to other restorative materials. Therefore, this dissertation aims to develop a new generation of dental composites with antibacterial effects, protein-repellent activities, and remineralization properties. Recently, a rechargeable composite was developed, but this composite has no antibacterial or protein-repellent activities. In this dissertation projects, the nanoparticles of amorphous calcium and phosphate (NACP) as remineralizing agent, dimethylaminohexadecyl methacrylate (DMAHDM) as an antibacterial monomer, and 2- metha-cryloyloxyethyl phosphorylcholine (MPC) as a protein-repellent agent were incorporated into the rechargeable composite for the first time. Mechanical properties of the new nanocomposites were evaluated. The characterization of protein adsorption was measured. A human saliva microcosm biofilm model was used to determine biofilm metabolic activity, lactic acid, and colony-forming units (CFU). Calcium (Ca) and Phosphate (P) initial ion release, recharge and re-release were investigated. All rechargeable nanocomposites have good mechanical properties that were compared to those of a commercial composite. The rechargeable nanocomposites containing MPC showed the ability to reduce protein adsorption, as well as the biofilm metabolic activity, lactic acid, and CFU. The rechargeable nanocomposites containing DMAHDM showed strong antibacterial properties through the great inhibition of biofilm metabolic activity and lactic acid, and CFU. The incorporation of bioactive agents did not compromise the Ca and P initial ion release and rechargeability. The release was maintained at the same level with increasing number of recharge cycles, indicating long-term ion release. Therefore, this new generation of rechargeable nanocomposites with long-term Ca and P ion release, antibacterial and protein-repellent activities will provide the needed therapeutic effects to remineralize and strengthen the tooth structures, prolong the restoration longevity, and inhibit secondary caries.en_US
dc.language.isoen_USen_US
dc.subjectanti-biofilmen_US
dc.subjectanti-cariesen_US
dc.subjectcalcium phosphate nanoparticlesen_US
dc.subjectdental compositeen_US
dc.subjection recharge and re-releaseen_US
dc.subjectprotein repellenten_US
dc.subject.meshBiofilmsen_US
dc.subject.meshComposite Resinsen_US
dc.subject.meshDental Caries--prevention & controlen_US
dc.subject.meshNanoparticles--therapeutic useen_US
dc.titleDevelopment of a New Generation of Dental Rechargeable Nanocomposites with Anti-caries Propertiesen_US
dc.typedissertationen_US
dc.contributor.advisorXu, Huakun H.
dc.description.urinameFull Texten_US
refterms.dateFOA2019-02-19T18:36:23Z


Files in this item

Thumbnail
Name:
AlDulaijan_umaryland_0373D_109 ...
Size:
5.488Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record