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dc.contributor.authorPatton, Mary
dc.date.accessioned2018-06-07T19:06:57Z
dc.date.available2018-06-07T19:06:57Z
dc.date.issued2018
dc.identifier.urihttp://hdl.handle.net/10713/7947
dc.descriptionUniversity of Maryland, Baltimore. Neuroscience. Ph.D. 2018en_US
dc.description.abstractThe brain dynamically interacts with the environment to ensure organism survival. Underlying this dynamism are plastic changes at synapses in a brain region known as the striatal complex that encodes the motivation to seek, and the motor skills required to obtain, rewards. Historically, work in the striatal complex has largely focused on synaptic changes at excitatory synapses. This is despite the ability for the major drug of abuse ethanol to alter both excitatory and inhibitory signaling in the striatal complex to foster alcohol use disorders. Using whole-cell electrophysiology in conjunction with ex vivo optogenetics and a variety of ethanol exposure models, I tested the effects of ethanol on the induction and maintenance of plastic changes at inhibitory synapses in the striatal complex. The work presented in this dissertation is the first to demonstrate that acute and chronic ethanol exposure in mice is capable of producing and enhancing long lasting inhibitory synaptic changes as well as altering the population activity of inhibitory interneurons. Through this work, I identify novel molecular targets to combat alcoholism and provide a clear path forward for future work in the field.en_US
dc.language.isoen_USen_US
dc.subjectdorsal striatumen_US
dc.subject.meshAlcoholsen_US
dc.subject.meshEthanolen_US
dc.subject.meshNeostriatumen_US
dc.subject.meshNeural Inhibitionen_US
dc.subject.meshNeuronal Plasticityen_US
dc.subject.meshNucleus Accumbensen_US
dc.titleEthanol modulation of striatal complex disinhibitionen_US
dc.typedissertationen_US
dc.contributor.advisorMathur, Brian N. (Brian Neil)en_US
dc.description.urinameFull Texten_US
refterms.dateFOA2019-02-19T18:01:12Z


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