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dc.contributor.authorLyke, Kirsten E.
dc.contributor.authorDabo, Abdoulaye
dc.contributor.authorArama, Charles
dc.contributor.authorDiarra, Issa
dc.contributor.authorPlowe, Christopher V.
dc.contributor.authorDoumbo, Ogobara K.
dc.contributor.authorSztein, Marcelo B.
dc.identifier.citationLyke KE, Dabo A, Arama C, Diarra I, Plowe CV, Doumbo OK, Sztein MB. (2018). Long-term Maintenance of CD4 T Cell Memory Responses to Malaria Antigens in Malian Children Coinfected with Schistosoma haematobium. Frontiers in Immunolology, 8:1995, DOI: 10.3389/fimmu.2017.01995en_US
dc.description.abstractPolyparasitism is common in the developing world. We have previously demonstrated that schistosomiasis-positive (SP) Malian children, aged 4–8 years, are protected from malaria compared to matched schistosomiasis-negative (SN) children. The effect of concomitant schistosomiasis upon acquisition of T cell memory is unknown. We examined antigen-specific T cell frequencies in 48 Malian children aged 4–14 to a pool of malaria blood stage antigens, and a pool of schistosomal antigens, at a time point during a malaria episode and at a convalescent time point ~6 months later, following cessation of malaria transmission. CD4+ T cell-derived memory responses, defined as one or more significant cytokine (IFN-γ, TNF-α, IL-2, and/or IL-17A) responses, was measured to schistoma antigens in 18/23 SP children at one or both time points, compared to 4/23 SN children (P < 0.0001). At the time of malaria infection, 12/24 SN children and 15/23 SP children (P = 0.29) stimulated with malaria antigens demonstrated memory recall as defined by CD4-derived cytokine production. This compares to 7/23 SN children and 16/23 SP children (P = 0.009) at the convalescent timepoint. 46.2% of cytokine-producing CD4+ T cells expressed a single cytokine after stimulation with malaria antigen during the malaria episode. This fell to 40.9% at follow-up with a compensatory rise of multifunctional cytokine secretion over time, a phenomenon consistent with memory maturation. The majority (53.2–59.5%) of responses derived from CD45RA−CD62L− effector memory T cells with little variation in the phenotype depending upon the time point or the study cohort. We conclude that detectable T cell memory responses can be measured against both malaria and schistosoma antigens and that the presence of Schistosoma haematobium may be associated with long-term maintenance of T memory to malaria.en_US
dc.publisherLausanne, Switzerland: Frontiersen_US
dc.rightsOpen Accessen_US
dc.subjectmultifunctional T cellsen_US
dc.subjectT cell memoryen_US
dc.subject.meshPlasmodium falciparumen_US
dc.subject.meshChild, Preschoolen_US
dc.titleLong-term Maintenance of CD4 T Cell Memory Responses to Malaria Antigens in Malian Children Coinfected with Schistosoma haematobiumen_US
dc.description.urinameFull Texten_US

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